Intervention Studies for the metabolite Enterodiol with food phytochemical Secoisolariciresinol diglucoside
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | 1.31 µmol SDG/kg body weight | Pure compound | 12 | Healthy; 6M;6F | 1.31 µmol/kg body weight | Single | 1 day | 14,8±5,1 | 73±40 (SD) | 966 | 0-24h | 4,4±1.3 (SD) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | 1.31 µmol SDG/kg body weight | Pure compound | 6 | 6M; Age=25Y; body weight=73.0± 6.2kg; BMI=21.5 ± 1.3 kg/m² | 1.31 µmol/kg body weight | Single | 1 day | 17,8±4,1 | 65±33 (SD) | 1019 | 0-24h | 4,6±1.1 (SD) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | 1.31 µmol SDG/kg body weight | Pure compound | 6 | 6F;Age=25Y; body weight=67.6 ± 4.5 kg; BMI=23.5 ± 1.6 kg/m² | 1.31 µmol/kg body weight | Single | 1 day | 11,7±4,1 | 81±47 (SD) | 914 | 0-24h | 4,1±1.5 (SD) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | oral bolus dose of 86 mg of a 43% pure secoisolariciresinol-diglycoside (SDG) extract | Extract | 10 | Healthy; post-menopausal | 86 mg | single | 13,2 | 35.3±6 (SEM) | 622 | 0-24h | 10.2±2.1 (SEM) | Publications | |||||
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | oral bolus dose of 172 mg of a 43% pure secoisolariciresinol-diglycoside (SDG) extract | Extract | 10 | Healthy; post-menopausal | 172 mg | single | 25,2 | 75.6±30 (SEM) | 1949 | 0-24h | 7.7±0.8 (SEM) | Publications | |||||
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | oral intake of 50 mg of secoisolariciresinol-diglycoside (SDG) in a 28.8% pure SDG extract given in a randomized double-blinded crossover design with a minimum one-week washout between | Extract | 5 | Healthy; post-menopausal | 50 mg | single | 18,3 | 17±1,7 (SEM) | 342 | 0-24h | 8.6±1.4 (SEM) | Publications | |||||
| Secoisolariciresinol diglucoside | Enterodiol | Human | Plasma; Urine | Gut microbiota metabolite | single-bolus oral intake of 50 mg of secoisolariciresinol-diglycoside (SDG) in a 74.4% pure SDG extract given in a randomized double-blinded crossover design with a minimum one-week washout between | Extract | 5 | Healthy; post-menopausal | 50 mg | single | 16 | 19±5 (SEM) | 404 | 0-24h | 11.2±1.6 (SEM) | Publications |