Intervention Studies for the metabolite Enterolactone with food phytochemical Secoisolariciresinol diglucoside

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma; Urine	Gut microbiota metabolite	1.31 µmol SDG/kg body weight	Pure compound	12	Healthy;6M;6F	1.31 µmol/kg body weight	Single	1 day	19,7±9,2	56±30 (SD)	1762	0-24h	12.6±5.6 (SD)			Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma; Urine	Gut microbiota metabolite	1.31 µmol SDG/kg body weight	Pure compound	6	6M; Age=25Y; body weight=73.0± 6.2kg; BMI=21.5±1.3 kg/m²	1.31 µmol/kg body weight	Single	1 day	24,1±4,5	42±22 (SD)	1706	0-24h	15.1±6.7 (SD)			Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma; Urine	Gut microbiota metabolite	1.31 µmol SDG/kg body weight	Pure compound	6	6F;Age=25Y; body weight=67.6 ± 4.5 kg; BMI=23.5±1.6 kg/m²	1.31 µmol/kg body weight	Single	1 day	15,4±4,2	70±32 (SD)	1817	0-24h	10.2±3.2 (SD)			Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Serum	Gut microbiota metabolite	500mg/day of SDG in a low-fat muffin	Extract	22	Healthy postmenopausal women; Age=61 ± 7Y	500 mg	multiple	6 weeks							385 nmol/L at 6 weeks±67 (SEM)	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma	Gut microbiota metabolite	0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG))	Food	12	Healthy; 6M; 6F; Age=18-64Y	0.3 µmol/kg body weight	multiple	10 days							20 nmol/L at 10 days±5 (SEM)	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma	Gut microbiota metabolite	0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG))	Food	12	Healthy; 6M; 6F; Age=18-64Y	0.3 µmol/kg body weight	multiple	10 days							37 nmol/L at 10 days±11 (SEM)	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma	Gut microbiota metabolite	0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG))	Food	12	Healthy; 6M; 6F; Age=18-64Y	0.3 µmol/kg body weight	multiple	10 days							103 nmol/L at 10 days±31 (SEM)	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma	Gut microbiota metabolite	600 mg SDG	Extract	18	Healthy; Age=60-80Y	600 mg	multiple	8 weeks							192.0 ng/mL at 8 weeks±257,6 (SEM)	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma	Gut microbiota metabolite	600 mg SDG	Extract	18	Healthy; Age=60-80Y	600 mg	multiple	16 weeks							196.1 ng/mL at 16 weeks±199,1 (SEM)	Publications
	Secoisolariciresinol diglucoside		Enterolactone	Human	Plasma	Gut microbiota metabolite	600 mg SDG	Extract	19	Healthy; Age=60-80Y	600 mg	multiple	24 weeks							164.2 ng/mL at 24 weeks±150,7 (SEM)	Publications

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