Intervention Studies for the metabolite Enterolactone with food phytochemical Secoisolariciresinol diglucoside
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | 1.31 µmol SDG/kg body weight | Pure compound | 12 | Healthy;6M;6F | 1.31 µmol/kg body weight | Single | 1 day | 19,7±9,2 | 56±30 (SD) | 1762 | 0-24h | 12.6±5.6 (SD) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | 1.31 µmol SDG/kg body weight | Pure compound | 6 | 6M; Age=25Y; body weight=73.0± 6.2kg; BMI=21.5±1.3 kg/m² | 1.31 µmol/kg body weight | Single | 1 day | 24,1±4,5 | 42±22 (SD) | 1706 | 0-24h | 15.1±6.7 (SD) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | 1.31 µmol SDG/kg body weight | Pure compound | 6 | 6F;Age=25Y; body weight=67.6 ± 4.5 kg; BMI=23.5±1.6 kg/m² | 1.31 µmol/kg body weight | Single | 1 day | 15,4±4,2 | 70±32 (SD) | 1817 | 0-24h | 10.2±3.2 (SD) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Serum | Gut microbiota metabolite | 500mg/day of SDG in a low-fat muffin | Extract | 22 | Healthy postmenopausal women; Age=61 ± 7Y | 500 mg | multiple | 6 weeks | 385 nmol/L at 6 weeks±67 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma | Gut microbiota metabolite | 0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG)) | Food | 12 | Healthy; 6M; 6F; Age=18-64Y | 0.3 µmol/kg body weight | multiple | 10 days | 20 nmol/L at 10 days±5 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma | Gut microbiota metabolite | 0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG)) | Food | 12 | Healthy; 6M; 6F; Age=18-64Y | 0.3 µmol/kg body weight | multiple | 10 days | 37 nmol/L at 10 days±11 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma | Gut microbiota metabolite | 0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG)) | Food | 12 | Healthy; 6M; 6F; Age=18-64Y | 0.3 µmol/kg body weight | multiple | 10 days | 103 nmol/L at 10 days±31 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma | Gut microbiota metabolite | 600 mg SDG | Extract | 18 | Healthy; Age=60-80Y | 600 mg | multiple | 8 weeks | 192.0 ng/mL at 8 weeks±257,6 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma | Gut microbiota metabolite | 600 mg SDG | Extract | 18 | Healthy; Age=60-80Y | 600 mg | multiple | 16 weeks | 196.1 ng/mL at 16 weeks±199,1 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma | Gut microbiota metabolite | 600 mg SDG | Extract | 19 | Healthy; Age=60-80Y | 600 mg | multiple | 24 weeks | 164.2 ng/mL at 24 weeks±150,7 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | oral bolus dose of 86 mg of a 43% pure secoisolariciresinol-diglycoside (SDG) extract | Extract | 10 | Healthy; post-menopausal | 86 mg | single | 1 day | 27,6 | 38.7±18 (SEM) | 1033 | 0-24h | 13.2±4.2 (SEM) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | oral bolus dose of 172 mg of a 43% pure secoisolariciresinol-diglycoside (SDG) extract | Extract | 10 | Healthy; post-menopausal | 172 mg | single | 1 day | 25,5 | 49.1±17 (SEM) | 1302 | 0-24h | 9.6±9.6 (SEM) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | oral intake of 50 mg of secoisolariciresinol-diglycoside (SDG) in a 28.8% pure SDG extract given in a randomized double-blinded crossover design with a minimum one-week washout between | Extract | 5 | Healthy; post-menopausal | 50 mg | single | 1 day | 24 | 16.8±3,7 (SEM) | 487 | 0-24h | 13.9±1.6 (SEM) | Publications | ||||
| Secoisolariciresinol diglucoside | Enterolactone | Human | Plasma; Urine | Gut microbiota metabolite | oral intake of 50 mg of secoisolariciresinol-diglycoside (SDG) in a 74.4% pure SDG extract given in a randomized double-blinded crossover design with a minimum one-week washout between | Extract | 5 | Healthy; post-menopausal | 50 mg | single | 1 day | 25,5 | 19.2±6,4 (SEM) | 538 | 0-24h | 15.8±5.3 (SEM) | Publications |