Intervention Studies for the metabolite (+)-Matairesinol with food phytochemical Secoisolariciresinol diglucoside

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Urine	Gut microbiota metabolite	500mg/day of SDG in a low-fat muffin	Extract	22	Healthy postmenopausal women; Age=61 ± 7Y	500 mg	multiple	6 weeks							94 µmol/day at 6 weeks±11 (SEM)	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Plasma	Gut microbiota metabolite	0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG))	Food	12	Healthy; 6M; 6F; Age=18-64Y	0.3 µmol/kg body weight	multiple	10 days							65 nmol/L at 10 days±16 (SEM)	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Plasma	Gut microbiota metabolite	0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG))	Food	12	Healthy; 6M; 6F; Age=18-64Y	0.3 µmol/kg body weight	multiple	10 days							85 nmol/L at 10 days±17 (SEM)	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Plasma	Gut microbiota metabolite	0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG))	Food	12	Healthy; 6M; 6F; Age=18-64Y	0.3 µmol/kg body weight	multiple	10 days							167nmol/L at 10 days±25 (SEM)	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Plasma	Gut microbiota metabolite	600 mg SDG	Extract	18	Healthy; Age=60-80Y	600 mg	multiple	8 weeks							349.6 ng/mL at 8 weeks±278,6 (SEM)	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Plasma	Gut microbiota metabolite	600 mg SDG	Extract	18	Healthy; Age=60-80Y	600 mg	multiple	16 weeks							464.2 ng/mL at 16 weeks±322,3 (SEM)	Publications
	Secoisolariciresinol diglucoside		(+)-Matairesinol	Human	Plasma	Gut microbiota metabolite	600 mg SDG	Extract	19	Healthy; Age=60-80Y	600 mg	multiple	24 weeks							312.7 ng/mL at 24 weeks±271 (SEM)	Publications

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