Intervention Studies for the metabolite (+)-Matairesinol with food phytochemical Secoisolariciresinol diglucoside
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Urine | Gut microbiota metabolite | 500mg/day of SDG in a low-fat muffin | Extract | 22 | Healthy postmenopausal women; Age=61 ± 7Y | 500 mg | multiple | 6 weeks | 94 µmol/day at 6 weeks±11 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Plasma | Gut microbiota metabolite | 0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG)) | Food | 12 | Healthy; 6M; 6F; Age=18-64Y | 0.3 µmol/kg body weight | multiple | 10 days | 65 nmol/L at 10 days±16 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Plasma | Gut microbiota metabolite | 0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG)) | Food | 12 | Healthy; 6M; 6F; Age=18-64Y | 0.3 µmol/kg body weight | multiple | 10 days | 85 nmol/L at 10 days±17 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Plasma | Gut microbiota metabolite | 0.3 g flaxseeds (3.6 mg/day of lignans (98% SDG)) | Food | 12 | Healthy; 6M; 6F; Age=18-64Y | 0.3 µmol/kg body weight | multiple | 10 days | 167nmol/L at 10 days±25 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Plasma | Gut microbiota metabolite | 600 mg SDG | Extract | 18 | Healthy; Age=60-80Y | 600 mg | multiple | 8 weeks | 349.6 ng/mL at 8 weeks±278,6 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Plasma | Gut microbiota metabolite | 600 mg SDG | Extract | 18 | Healthy; Age=60-80Y | 600 mg | multiple | 16 weeks | 464.2 ng/mL at 16 weeks±322,3 (SEM) | Publications | ||||||||
| Secoisolariciresinol diglucoside | (+)-Matairesinol | Human | Plasma | Gut microbiota metabolite | 600 mg SDG | Extract | 19 | Healthy; Age=60-80Y | 600 mg | multiple | 24 weeks | 312.7 ng/mL at 24 weeks±271 (SEM) | Publications |