Intervention Studies for the metabolite Hydroxytyrosol acetate sulfate with food phytochemical Virgin olive oil Secoiridoids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Virgin olive oil Secoiridoids | Hydroxytyrosol acetate sulfate | Human | Plasma | Non enzymatic and host metabolism | 30 mL/day (3 weeks) of a functional low phenol-enriched virgin olive oil | Food | 15 | Healthy; 6M; 6W | 2,23 mg | Single | 6 h | 1 | 0,46±0,26 (SD) | 85,5 | (0-6h) | Publications | |||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol acetate sulfate | Human | Plasma | Non enzymatic and host metabolism | 30 mL/day (3 weeks) of a functional medium phenol-enriched virgin olive oil | Food | 15 | Healthy; 6M; 6W | 6,27 mg | Single | 6 h | 2 | 1,89±1,63 (SD) | 292 | (0-6h) | Publications | |||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol acetate sulfate | Human | Plasma | Non enzymatic and host metabolism | 30 mL/day (3 weeks) of a functional high phenol-enriched virgin olive oil | Food | 15 | Healthy; 6M; 6W | 10,87 mg | Single | 6 h | 1 | 2,24±0,51 (SD) | 383 | (0-6h) | 0.4 to (0-24h) | Publications | ||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol acetate sulfate | Human | Urine | Host metabolism | 25 mL/day (3 weeks) of a functional low phenol-enriched virgin olive oil | Food | 33 | Hypercholesterolemic (total cholesterol > 200 mg/dL); 19M; 14W | 0,31 mg | Multiple | 21 days | 4.0 to (0-24h) | Publications | ||||||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol acetate sulfate | Human | Urine | Host metabolism | 25 mL/day (3 weeks) of a functional medium phenol-enriched virgin olive oil | Food | 33 | Hypercholesterolemic (total cholesterol > 200 mg/dL); 19M; 14W | 8,49 mg | Multiple | 21 days | 0.9 to (0-24h) | Publications | ||||||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol acetate sulfate | Human | Urine | Host metabolism | 25 mL/day (3 weeks) of a functional virgin olive oil enriched with its own phenolic compounds and with phenolic compounds from thyme | Food | 33 | Hypercholesterolemic (total cholesterol > 200 mg/dL); 19M; 14W | 4,36 mg | Multiple | 21 days | Publications |