Intervention Studies for the metabolite Hydroxytyrosol glucuronide with food phytochemical Virgin olive oil Secoiridoids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Virgin olive oil Secoiridoids | Hydroxytyrosol glucuronide | Human | Urine | Host metabolism | 25 mL/day (3 weeks) of a functional low phenol-enriched virgin olive oil | Food | 33 | Hypercholesterolemic (total cholesterol > 200 mg/dL); 19M; 14W | 0,31 mg | Multiple | 21 days | 2,78 | 1.3e-05-5.6e-05 ng/mL (0-24h) | Publications | |||||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol glucuronide | Human | Urine | Host metabolism | 25 mL/day (3 weeks) of a functional medium phenol-enriched virgin olive oil | Food | 33 | Hypercholesterolemic (total cholesterol > 200 mg/dL); 19M; 14W | 8,49 mg | Multiple | 21 days | 2,87 | 1.5e-05-0.00031 ng/mL (0-24h) | Publications | |||||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol glucuronide | Human | Urine | Host metabolism | 25 mL/day (3 weeks) of a functional virgin olive oil enriched with its own phenolic compounds and with phenolic compounds from thyme | Food | 33 | Hypercholesterolemic (total cholesterol > 200 mg/dL); 19M; 14W | 4,36 mg | Multiple | 21 days | 0,29 | 0.55–1.34 µmol (0-24h) | Publications | |||||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol glucuronide | Human | Plasma | Unchanged | dissolved in 100 ml of sugarless lemonade | pure compound | 10 | Healthy; F in ovulatory phase; Age= 23.5±4.7 y | 300 mg | Single | 1,47±0,56 (SD) | 7,55±1,96 (SD) | 93 | (0-24h) | 7,79±2,48 (SD) | Publications | |||||
| Virgin olive oil Secoiridoids | Hydroxytyrosol glucuronide | Human | Plasma | Unchanged | capsules with 150 mL water + multiples doses quercetin capsules | pure compound | 6 | Healthy; M; heterozygous for the CYP1A2∗1C/∗1F (GA/CA)genotype; Chinese | 100 mg | Single | 1,50±(0.9, 3.0) (CI) | 20,4±(12.8, 28.1) (CI) | 122 | (0-24h) | 4,1±(3.5-4.7) (CI) | Publications |