Intervention Studies for the metabolite Theobromine with food phytochemical Caffeine
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caffeine | Theobromine | Human | Plasma | Host metabolism | 350 mL of coffee beverage | food | 13 | Healthy; 6 F (Age = 24–28 y); 7 M (Age= 27–30 y) | 224 mg | Single | 6,00 | 0,508±0,372 (SD) | Publications | ||||||||
| Caffeine | Theobromine | Human | Urine | Host metabolism | NoDoz® caplets + 180 mL water | pure compound | 15 | 200 mg | Single | 0,96 | 1.91mg±0,94 (0-24h) (SD) ((0-24h)) | Publications | |||||||||
| Caffeine | Theobromine | Human | Urine | Host metabolism | gelatin capsules with water | pure compound | 107 | Healthy; 52 M; 55 F; Age= 22 ± 3 y; Spanish | 300 mg | Single | 1,28±0,1 (SEM) | Publications | |||||||||
| Caffeine | Theobromine | Human | Urine | Host metabolism | 70 mL of acqueous solution | pure compound | 4 | Healthy;M; Age= 26-36 y | 350 mg | Single | 2,40±0,3 (SEM) | Publications | |||||||||
| Caffeine | Theobromine | Human | Urine | Host metabolism | dissolved in water | pure compound | 63 | Healthy; 35 M; 33 F; Age= 26.6 y ; 42 Caucasians; 26 Oriental | 300 mg | Single | 1,10±0,6 (SD) | Publications | |||||||||
| Caffeine | Theobromine | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 5 | Healthy; Age= 69.6±2.3 y; caucasians | 0,005 g/Kg bw | Single | 1,22±0,79 (SD) | Publications | |||||||||
| Caffeine | Theobromine | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 7 | Healthy; age 22.2±4.0 y; caucasians | 0,005 g/Kg bw | Single | 2,04±1,96 (SD) | Publications | |||||||||
| Caffeine | Theobromine | Human | Plasma | Host metabolism | tablets | pure compound | 8 | Healthy; M; Age= 27 y | 200 mg | Single | 2,00 | 8 | 2,60 | Publications |