Publications for the metabolite Caffeine with food phytochemical Caffeine

1. Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM: Effect of venlafaxine on CYP1A2-dependent pharmacokinetics and metabolism of caffeine. J Clin Pharmacol. 1999 Mar;39(3):252-9. [PubMed:10073324 ]
2. Abernethy DR, Todd EL: Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol. 1985;28(4):425-8. doi: 10.1007/BF00544361. [PubMed:4029248 ]
3. Bonati M, Latini R, Galletti F, Young JF, Tognoni G, Garattini S: Caffeine disposition after oral doses. Clin Pharmacol Ther. 1982 Jul;32(1):98-106. doi: 10.1038/clpt.1982.132. [PubMed:7083737 ]
4. Bchir F, Dogui M, Ben Fradj R, Arnaud MJ, Saguem S: Differences in pharmacokinetic and electroencephalographic responses to caffeine in sleep-sensitive and non-sensitive subjects. C R Biol. 2006 Jul;329(7):512-9. doi: 10.1016/j.crvi.2006.01.006. Epub 2006 May 6. [PubMed:16797457 ]
5. Hammami MM, Alvi SN: Large Intra-subject Variability in Caffeine Pharmacokinetics: Randomized Cross-over Study of Single Caffeine Product. Drug Res (Stuttg). 2017 Sep;67(9):539-546. doi: 10.1055/s-0043-110144. Epub 2017 May 23. [PubMed:28561231 ]
6. van der Merwe PJ, Muller FR, Muller FO: Caffeine in sport. Urinary excretion of caffeine in healthy volunteers after intake of common caffeine-containing beverages. S Afr Med J. 1988 Aug 20;74(4):163-4. [PubMed:3406872 ]
7. Beach CA, Bianchine JR, Gerber N: The excretion of caffeine in the semen of men: pharmacokinetics and comparison of the concentrations in blood and semen. J Clin Pharmacol. 1984 Feb-Mar;24(2-3):120-6. doi: 10.1002/j.1552-4604.1984.tb02774.x. [PubMed:6715563 ]
8. Blanchard J, Sawers SJ, Jonkman JH, Tang-Liu DD: Comparison of the urinary metabolite profile of caffeine in young and elderly males. Br J Clin Pharmacol. 1985 Feb;19(2):225-32. doi: 10.1111/j.1365-2125.1985.tb02635.x. [PubMed:3986081 ]
9. Blanchard J, Sawers SJ: Comparative pharmacokinetics of caffeine in young and elderly men. J Pharmacokinet Biopharm. 1983 Apr;11(2):109-26. doi: 10.1007/BF01061844. [PubMed:6886969 ]
10. Collomp K, Anselme F, Audran M, Gay JP, Chanal JL, Prefaut C: Effects of moderate exercise on the pharmacokinetics of caffeine. Eur J Clin Pharmacol. 1991;40(3):279-82. doi: 10.1007/BF00315209. [PubMed:2060565 ]
11. Campbell ME, Spielberg SP, Kalow W: A urinary metabolite ratio that reflects systemic caffeine clearance. Clin Pharmacol Ther. 1987 Aug;42(2):157-65. doi: 10.1038/clpt.1987.126. [PubMed:3608349 ]
12. Carrillo JA, Benitez J: Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways. Clin Pharmacol Ther. 1994 Mar;55(3):293-304. doi: 10.1038/clpt.1994.30. [PubMed:8143395 ]
13. Cysneiros RM, Farkas D, Harmatz JS, von Moltke LL, Greenblatt DJ: Pharmacokinetic and pharmacodynamic interactions between zolpidem and caffeine. Clin Pharmacol Ther. 2007 Jul;82(1):54-62. doi: 10.1038/sj.clpt.6100211. Epub 2007 Apr 18. [PubMed:17443132 ]
14. Carbo M, Segura J, De la Torre R, Badenas JM, Cami J: Effect of quinolones on caffeine disposition. Clin Pharmacol Ther. 1989 Mar;45(3):234-40. doi: 10.1038/clpt.1989.23. [PubMed:2920498 ]
15. Jeppesen U, Loft S, Poulsen HE, Brsen K: A fluvoxamine-caffeine interaction study. Pharmacogenetics. 1996 Jun;6(3):213-22. doi: 10.1097/00008571-199606000-00003. [PubMed:8807660 ]
16. Martinez-Lopez S, Sarria B, Baeza G, Mateos R, Bravo-Clemente L: Pharmacokinetics of caffeine and its metabolites in plasma and urine after consuming a soluble green/roasted coffee blend by healthy subjects. Food Res Int. 2014 Oct;64:125-133. doi: 10.1016/j.foodres.2014.05.043. Epub 2014 Jun 11. [PubMed:30011631 ]
17. Martínez-López S, Sarriá B, Gómez-Juaristi M, Goya L, Mateos R, Bravo-Clemente L: Theobromine, caffeine, and theophylline metabolites in human plasma and urine after consumption of soluble cocoa products with different methylxanthine contents Food Research International. 2014 March 14;63:446-455.
18. Morton K, Knight K, Kalman D, Hewlings S: A Prospective Randomized, Double-Blind, Two-Period Crossover Pharmacokinetic Trial Comparing Green Coffee Bean Extract-A Botanically Sourced Caffeine-With a Synthetic USP Control. Clin Pharmacol Drug Dev. 2018 Nov;7(8):871-879. doi: 10.1002/cpdd.451. Epub 2018 Apr 16. [PubMed:29659178 ]
19. Mumford GK, Benowitz NL, Evans SM, Kaminski BJ, Preston KL, Sannerud CA, Silverman K, Griffiths RR: Absorption rate of methylxanthines following capsules, cola and chocolate. Eur J Clin Pharmacol. 1996;51(3-4):319-25. doi: 10.1007/s002280050205. [PubMed:9010706 ]
20. Haller CA, Jacob P 3rd, Benowitz NL: Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Clin Pharmacol Ther. 2004 Apr;75(4):259-73. doi: 10.1016/j.clpt.2003.11.375. [PubMed:15060505 ]
21. Kamimori GH, Somani SM, Knowlton RG, Perkins RM: The effects of obesity and exercise on the pharmacokinetics of caffeine in lean and obese volunteers. Eur J Clin Pharmacol. 1987;31(5):595-600. doi: 10.1007/BF00606637. [PubMed:3830245 ]
22. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS, Shader RI: Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997 Aug;37(8):693-703. doi: 10.1002/j.1552-4604.1997.tb04356.x. [PubMed:9378841 ]
23. Kamimori GH, Joubert A, Otterstetter R, Santaromana M, Eddington ND: The effect of the menstrual cycle on the pharmacokinetics of caffeine in normal, healthy eumenorrheic females. Eur J Clin Pharmacol. 1999 Aug;55(6):445-9. doi: 10.1007/s002280050654. [PubMed:10492057 ]
24. Newton R, Broughton LJ, Lind MJ, Morrison PJ, Rogers HJ, Bradbrook ID: Plasma and salivary pharmacokinetics of caffeine in man. Eur J Clin Pharmacol. 1981;21(1):45-52. doi: 10.1007/BF00609587. [PubMed:7333346 ]
25. Perera V, Gross AS, Xu H, McLachlan AJ: Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics. J Pharm Pharmacol. 2011 Sep;63(9):1161-8. doi: 10.1111/j.2042-7158.2011.01326.x. Epub 2011 Jul 6. [PubMed:21827488 ]
26. Syed SA, Kamimori GH, Kelly W, Eddington ND: Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers. Biopharm Drug Dispos. 2005 Dec;26(9):403-9. doi: 10.1002/bdd.469. [PubMed:16158445 ]
27. Maish WA, Hampton EM, Whitsett TL, Shepard JD, Lovallo WR: Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics. Pharmacotherapy. 1996 Nov-Dec;16(6):1046-52. [PubMed:8947977 ]
28. Kamimori GH, Karyekar CS, Otterstetter R, Cox DS, Balkin TJ, Belenky GL, Eddington ND: The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm. 2002 Mar 2;234(1-2):159-67. doi: 10.1016/s0378-5173(01)00958-9. [PubMed:11839447 ]
29. Xiao J, Huang WH, Peng JB, Tan ZR, Ou-Yang DS, Hu DL, Zhang W, Chen Y: Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C (-2964G>A) and *1F (734C>A) gene polymorphisms. Biomed Res Int. 2014;2014:405071. doi: 10.1155/2014/405071. Epub 2014 Jun 15. [PubMed:25025048 ]
30. Krieger DR, Kalman DS, Feldman S, Arnillas L, Goldberg D, Gisbert O, Nader S: The Safety, Pharmacokinetics, and Nervous System Effects of Two Natural Sources of Caffeine in Healthy Adult Males. Clin Transl Sci. 2016 Oct;9(5):246-251. doi: 10.1111/cts.12403. Epub 2016 Jun 20. [PubMed:27320048 ]
31. McDanell RE, Henderson LA, Russell K, McLean AE: The effect of brassica vegetable consumption on caffeine metabolism in humans. Hum Exp Toxicol. 1992 May;11(3):167-72. doi: 10.1177/096032719201100304. [PubMed:1352111 ]
32. McLean C, Graham TE: Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women. J Appl Physiol (1985). 2002 Oct;93(4):1471-8. doi: 10.1152/japplphysiol.00762.2000. [PubMed:12235049 ]
33. May DC, Jarboe CH, VanBakel AB, Williams WM: Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther. 1982 May;31(5):656-61. doi: 10.1038/clpt.1982.91. [PubMed:7075114 ]
34. Stille W, Harder S, Mieke S, Beer C, Shah PM, Frech K, Staib AH: Decrease of caffeine elimination in man during co-administration of 4-quinolones. J Antimicrob Chemother. 1987 Nov;20(5):729-34. doi: 10.1093/jac/20.5.729. [PubMed:3480885 ]
35. Lake CR, Rosenberg DB, Gallant S, Zaloga G, Chernow B: Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther. 1990 Jun;47(6):675-85. doi: 10.1038/clpt.1990.93. [PubMed:2357862 ]
36. Lane JD, Steege JF, Rupp SL, Kuhn CM: Menstrual cycle effects on caffeine elimination in the human female. Eur J Clin Pharmacol. 1992;43(5):543-6. doi: 10.1007/BF02285099. [PubMed:1483492 ]
37. Lelo A, Birkett DJ, Robson RA, Miners JO: Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man. Br J Clin Pharmacol. 1986 Aug;22(2):177-82. doi: 10.1111/j.1365-2125.1986.tb05246.x. [PubMed:3756065 ]
38. Mahr G, Sorgel F, Granneman GR, Kinzig M, Muth P, Patterson K, Fuhr U, Nickel P, Stephan U: Effects of temafloxacin and ciprofloxacin on the pharmacokinetics of caffeine. Clin Pharmacokinet. 1992;22 Suppl 1:90-7. doi: 10.2165/00003088-199200221-00015. [PubMed:1319876 ]
39. Gonzalez AM, Hoffman JR, Wells AJ, Mangine GT, Townsend JR, Jajtner AR, Wang R, Miramonti AA, Pruna GJ, LaMonica MB, Bohner JD, Hoffman MW, Oliveira LP, Fukuda DH, Fragala MS, Stout JR: Effects of time-release caffeine containing supplement on metabolic rate, glycerol concentration and performance. J Sports Sci Med. 2015 May 8;14(2):322-32. eCollection 2015 Jun. [PubMed:25983581 ]
40. Nicolau DP, Nightingale CH, Tessier PR, Fu Q, Xuan DW, Esguerra EM, Quintiliani R: The effect of fleroxacin and ciprofloxacin on the pharmacokinetics of multiple dose caffeine. Drugs. 1995;49 Suppl 2:357-9. doi: 10.2165/00003495-199500492-00097. [PubMed:8549360 ]
41. Schmider J, Brockmoller J, Arold G, Bauer S, Roots I: Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine. Pharmacogenetics. 1999 Dec;9(6):725-34. doi: 10.1097/01213011-199912000-00007. [PubMed:10634135 ]
42. Rodopoulos N, Norman A: Assessment of dimethylxanthine formation from caffeine in healthy adults: comparison between plasma and saliva concentrations and urinary excretion of metabolites. Scand J Clin Lab Invest. 1996 May;56(3):259-68. doi: 10.3109/00365519609088615. [PubMed:8761530 ]
43. Lang R, Dieminger N, Beusch A, Lee YM, Dunkel A, Suess B, Skurk T, Wahl A, Hauner H, Hofmann T: Bioappearance and pharmacokinetics of bioactives upon coffee consumption. Anal Bioanal Chem. 2013 Oct;405(26):8487-503. doi: 10.1007/s00216-013-7288-0. Epub 2013 Aug 28. [PubMed:23982107 ]