Intervention Studies for the metabolite Caffeine with food phytochemical Caffeine

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	82 g chocolate candy	food	7	Healthy; 3 M; 4 F; Age= 35 y	442 mg	Single		2,00	1,5±(0.81–2.19) (CI)						Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	25 g of cocoa dissolved in 200 mL semi-skimmed milk	food	13	Healthy; 3 M; 10 F; Age= 29.6 ± 4.2 y; BMI 22.9 ± 0.6 kg/m²	256 mg	Single		2,00±1,1 (SD)	12,1±2,6 (SD)	58,2	(0-8h)				Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	15 g of cocoa dissolved in 200 mL semi-skimmed milk	food	13	Healthy; 3 M; 10 F; Age= 29.6 ± 4.2 y; BMI 22.9 ± 0.6 kg/m²	94,35 mg	Single		2,10±2 (SD)	2,1±1,3 (SD)	10,8	(0-8h)				Publications
	Caffeine		Caffeine	Human	Urine	Unchanged	600 mL of coffee	food	9	Healthy; 4 M; 5 F; Age= 20.5 ± 6.3 y	0,01445 g/Kg bw	Single							0,74±0,4 (SD)	7019.7µg±3760,4 (0-24h) (SD) ((0-24h))	Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	2 g Nescafe Gold Blend in 200 ml water and 600 g of lightly steamed cabbage	food	4	Healthy; M	60 mg	Single		0,34	2,25±0,1 (SD)			3,21			Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	1 g Nescafe Gold Blend in 100 ml water and 400 g of lightly steamed cabbage	food	6	Healthy; 3 M; 3 F	30 mg	Single		0,40	1,45±0,65 (SD)			3,4			Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	1 g Nescafe Gold Blend in 100 ml water	food	6	Healthy; 3 M; 3 F	30 mg	Single		0,46	1,18±0,23 (SD)			3,96			Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	2 g Nescafe Gold Blend in 200 ml water	food	4	Healthy; M	60 mg	Single		0,43	1,85±0,5 (SD)			3,96			Publications
	Caffeine		Caffeine	Human	Plasma	Unchanged	350 mL of coffee beverage	food	13	Healthy; 6 F (Age = 24–28 y); 7 M (Age= 27–30 y)	224 mg	Single		1,00	32926±7488 (SD)						Publications
	Caffeine		Caffeine	Human	Serum	Unchanged	480 mg of green coffee bean extract in water	extract	15	Healthy; M	60 mg	Single		0,75	1,91±0,88 (SD)	6,35	(0-4h)				Publications

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