Intervention Studies for the metabolite Theophylline with food phytochemical Caffeine
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caffeine | Theophylline | Human | Urine | Host metabolism | gelatin capsules with water | pure compound | 107 | Healthy; 52 M; 55 F; Age= 22 ± 3 y; Spanish | 300 mg | Single | 0,50±0,04 (SEM) | Publications | |||||||||
| Caffeine | Theophylline | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 5 | Healthy; Age= 69.6±2.3 y; caucasians | 0,005 g/Kg bw | Single | 0,48±0,31 (SD) | Publications | |||||||||
| Caffeine | Theophylline | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 7 | Healthy; age 22.2±4.0 y; caucasians | 0,005 g/Kg bw | Single | 0,77±0,69 (SD) | Publications | |||||||||
| Caffeine | Theophylline | Human | Urine | Host metabolism | dissolved in water | pure compound | 68 | Healthy; 35 M; 33 F; Age= 26.6 y ; 42 Caucasians; 26 Oriental | 300 mg | Single | 1,00 | Publications | |||||||||
| Caffeine | Theophylline | Human | Plasma | Host metabolism | tablets | pure compound | 8 | Healthy; M; Age= 27 y | 200 mg | Single | 2,00 | 1 | 2,80 | Publications | |||||||
| Caffeine | Theophylline | Human | Plasma | Host metabolism | capsules with 200 mL water | pure compound | 12 | Healthy; Age= 18–35 y | 500 mg | Single | 1,21 | (0-8h) | Publications | ||||||||
| Caffeine | Theophylline | Human | Plasma | Host metabolism | capsules with 250 mL water | pure compound | 12 | Healthy; 5 M; 7 F; Age= 28.8±6.6 y | 500 mg | Single | 1.67 | (0-8h) | Publications | ||||||||
| Caffeine | Theophylline | Human | Plasma | Host metabolism | capsules with 250 mL water | pure compound | 12 | Healthy; 5 M; 7 F; Age= 28.8±6.6 y | 250 mg | Single | 1 | (0-8h) | Publications | ||||||||
| Caffeine | Theophylline | Human | Plasma | Host metabolism | 2 tablets | pure compound | 10 | Healthy; 7 M; 3 F; Age= 35±6 y | 200 mg | Single | 26 | (0-24h) | Publications | ||||||||
| Caffeine | Theophylline | Human | Plasma | Host metabolism | capsules with 200 mL water | pure compound | 12 | Healthy; Age= 18–35 y | 250 mg | Single | 0,83 | (0-8h) | Publications |