Intervention Studies for the metabolite Theophylline with food phytochemical Caffeine

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Caffeine		Theophylline	Human	Urine	Host metabolism	gelatin capsules with water	pure compound	107	Healthy; 52 M; 55 F; Age= 22 ± 3 y; Spanish	300 mg	Single							0,50±0,04 (SEM)		Publications
	Caffeine		Theophylline	Human	Urine	Host metabolism	dissolved in 200 mL water	pure compound	5	Healthy; Age= 69.6±2.3 y; caucasians	0,005 g/Kg bw	Single							0,48±0,31 (SD)		Publications
	Caffeine		Theophylline	Human	Urine	Host metabolism	dissolved in 200 mL water	pure compound	7	Healthy; age 22.2±4.0 y; caucasians	0,005 g/Kg bw	Single							0,77±0,69 (SD)		Publications
	Caffeine		Theophylline	Human	Urine	Host metabolism	dissolved in water	pure compound	68	Healthy; 35 M; 33 F; Age= 26.6 y ; 42 Caucasians; 26 Oriental	300 mg	Single							1,00		Publications
	Caffeine		Theophylline	Human	Plasma	Host metabolism	tablets	pure compound	8	Healthy; M; Age= 27 y	200 mg	Single		2,00	1				2,80		Publications
	Caffeine		Theophylline	Human	Plasma	Host metabolism	capsules with 200 mL water	pure compound	12	Healthy; Age= 18–35 y	500 mg	Single				1,21	(0-8h)				Publications
	Caffeine		Theophylline	Human	Plasma	Host metabolism	capsules with 250 mL water	pure compound	12	Healthy; 5 M; 7 F; Age= 28.8±6.6 y	500 mg	Single				1.67	(0-8h)				Publications
	Caffeine		Theophylline	Human	Plasma	Host metabolism	capsules with 250 mL water	pure compound	12	Healthy; 5 M; 7 F; Age= 28.8±6.6 y	250 mg	Single				1	(0-8h)				Publications
	Caffeine		Theophylline	Human	Plasma	Host metabolism	2 tablets	pure compound	10	Healthy; 7 M; 3 F; Age= 35±6 y	200 mg	Single				26	(0-24h)				Publications
	Caffeine		Theophylline	Human	Plasma	Host metabolism	capsules with 200 mL water	pure compound	12	Healthy; Age= 18–35 y	250 mg	Single				0,83	(0-8h)				Publications

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