Intervention Studies for the metabolite Hesperetin with food phytochemical Hesperidin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hesperidin | Hesperetin | Human | Plasma and Urine | Gut microbiota metabolite | Orange juice providing 61mg of hesperidin treated with autoclaved hesperidinase (20.1U/L) | food | 16 | Healthy; 8M;8F; Age=3 36 ±7; BMI= 21.8 ± 1,8 kg/m². | 300 mL | Single | 7.0±3.0 (SD) | 0.48±0.27 (SD) | 1.16 | 0-10 h | 4.06 (SD) | no data available±1.77 (SD) | Publications | ||||
| Hesperidin | Hesperetin | Human | Plasma and Urine | Gut microbiota metabolite | Orange juice providing 192mg of hesperidin treated with autoclaved hesperidinase (20.1U/L) | food | 16 | Healthy; 8M;8F; Age=3 36 ±7; BMI= 21.8 ± 1,8 kg/m² | 900 mL | Single | 7.4±2.0 (SD) | 1.05±0.25 (SD) | 4.16 | 0-10 h | 8.90 (SD) | no data available±3.83 (SD) | Publications | ||||
| Hesperidin | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 mL of fresh orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 18.8 mg of ( Hesperetin-7-rutinoside-3'-glucoside, Hesperetin-7-rutinoside) | Multiple | 3 weeks | 8.1 (SD) | 1,5±1.4 mg (SD) (0-24h) | Publications | |||||||
| Hesperidin | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 mL of high pressure homogenized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 51.6 mg of ( Hesperetin-7-rutinoside-3'-glucoside, Hesperetin-7-rutinoside) | Multiple | 3 weeks | 4.8 (SD) | 2,5±1.1 mg (SD) (0-24h) | Publications | |||||||
| Hesperidin | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 mL of pasteurized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 56.2 mg of ( Hesperetin-7-rutinoside-3'-glucoside, Hesperetin-7-rutinoside) | Multiple | 3 weeks | 3.3 (SD) | 1,9±0.5 mg (SD) (0-24h) | Publications | |||||||
| Hesperidin | Hesperetin | Human | Plasma; Urine | Gut microbiota metabolite | Orange juice providing 61mg of hesperidin treated with autoclaved hesperidinase (20.1U/L) | food | 16 | Healthy; 8M;8F; Age=3 36 ±7; BMI= 21.8 ± 1,8 kg/m². | 300 mL | Single | 7.0±3.0 (SD) | 0.48±0.27 (SD) | 1.16 | 0-10 h | 4.06±1.77 (SD) | Publications | |||||
| Hesperidin | Hesperetin | Human | Plasma; Urine | Gut microbiota metabolite | Orange juice providing 192mg of hesperidin treated with autoclaved hesperidinase (20.1U/L) | food | 16 | Healthy; 8M;8F; Age=3 36 ±7; BMI= 21.8 ± 1,8 kg/m² | 900 mL | Single | 7.4±2.0 (SD) | 1.05±0.25 (SD) | 4.16 | 0-10 h | 8.90±3.83 (SD) | no data available (SD) | Publications | ||||
| Hesperidin | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 mL of fresh orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 18.8 mg of ( Hesperetin-7-rutinoside-3'-glucoside, Hesperetin-7-rutinoside) | Multiple | 3 weeks | 8,1±1,4 (SD) | 1,5±0,3 mg (SD) (0-24h) | Publications | |||||||
| Hesperidin | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 mL of high pressure homogenized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 51.6 mg of ( Hesperetin-7-rutinoside-3'-glucoside, Hesperetin-7-rutinoside) | Multiple | 3 weeks | 4,8±1,1 (SD) | 2,5±0,6 mg (SD) (0-24h) | Publications | |||||||
| Hesperidin | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 mL of pasteurized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 56.2 mg of ( Hesperetin-7-rutinoside-3'-glucoside, Hesperetin-7-rutinoside) | Multiple | 3 weeks | 3,3±0,5 (SD) | 1,9±0,3 mg (SD) (0-24h) | Publications |