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Version 1.4

Intervention Studies for the metabolite Theobromine with food phytochemical Theobromine

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Food PhytochemicalMetaboliteSpeciesBiofluidsOriginDietary Source DescriptionDietary Source ClassificationTotal Number of SubjectsDescription of PopulationIngested AmountSingle/Multiple DoseDuration of the StudyTmax (h)Cmax (nM)AUC (nM/h)Time covered by AUC (h)t 1/2 (h)% of 24h Urinary ExcretionExcreted Amount & Time IntervalPublications
Food Phytochemical
Metabolite
Species
Biofluids
Origin
Dietary Source Description
Dietary Source Classification
Total Number of Subjects
Description of Population
Ingested Amount
Single/Multiple Dose
Duration of the Study
Tmax (h)
Cmax (nM)
AUC (nM/h)
Time covered by AUC (h)
t 1/2 (h)
% of 24h Urinary Excretion
Excreted Amount & Time Interval
Publications
Theobromine TheobromineHumanPlasmaUnchanged40 g of black chocolatefood8Healthy; M; Age= 40±15 y; BMI= 23.94±2.35kg/m²405 mgSingle2,25±0,88 (SD)6,365±0,894 (SD)74(0-8h)6,69±1,41 (SD) Publications
Theobromine TheobromineHumanPlasmaUnchanged80 g of black chocolatefood8Healthy; M; Age= 40±15 y; BMI= 23.94±2.35kg/m²810 mgSingle3,25±0,45 (SD)11,414±1,19 (SD)159(0-8h)8,15±1,66 (SD) Publications
Theobromine TheobromineHumanPlasmaUnchanged82 g chocolate candyfood7Healthy; 3 M; 4 F; Age= 35 y442 mgSingle2,00 8,05±(5.64–10.45) (CI) Publications
Theobromine TheobromineHumanPlasmaUnchanged25 g of cocoa dissolved in 200 mL semi-skimmed milkfood13Healthy; 3 M; 10 F; Age= 29.6 ± 4.2 y; BMI 22.9 ± 0.6 kg/m²256 mgSingle2,20±1,1 (SD)51,9±13 (SD)262,2(0-8h) Publications
Theobromine TheobromineHumanPlasmaUnchanged15 g of cocoa dissolved in 200 mL semi-skimmed milkfood13Healthy; 3 M; 10 F; Age= 29.6 ± 4.2 y; BMI 22.9 ± 0.6 kg/m²94,35 mgSingle1,90±1 (SD)15,8±3,3 (SD)88,8(0-8h) Publications
Theobromine TheobromineHumanPlasmaUnchanged3.5 g green–roasted coffee beverage (250 mL)food12Healthy; 7 M; 5 F; Age= 28.3 ± 0.7 y; BMI 22.9 ± 0.7 kg/m²70,809 mgSingle7,08±2,43 (SD)0,51±0,08 (SD)4,56(0-12h) Publications
Theobromine TheobromineHumanPlasma; UrineUnchangedsolution of distilled waterpure compound6Healthy; M; Age= 22-28 y0,01 g/Kg bwSingle117,6(0-inf)9,28±0,7 (SEM)18,20±2,1 (SEM) Publications
Theobromine TheobromineHumanPlasmaUnchangedgelatin capsules + 150 mL waterpure compound6Healthy; M; Age= 19-21 y250 mgSingle7,2±1,6 (SD) Publications
Theobromine TheobromineHumanPlasmaUnchanged2 capsules 185 mg each + 360 mL waterpure compound7Healthy; 3 M; 4 F; Age= 35 y370 mgSingle2,50 6,72±(4.76–8.68) (CI) Publications
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