Intervention Studies for the metabolite 3-methylxanthine with food phytochemical Cocoa purines
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa purines | 3-methylxanthine | Human | Plasma | Host metabolism | 25 g of cocoa dissolved in 200 mL semi-skimmed milk | food | 13 | Healthy; 3 M; 10 F; Age= 29.6 ± 4.2 y; BMI 22.9 ± 0.6 kg/m² | 256 mg | Single | 2,20±2,5 (SD) | 1,8±0,9 (SD) | 9,9 | (0-8h) | Publications | ||||||
| Cocoa purines | 3-methylxanthine | Human | Plasma | Host metabolism | 15 g of cocoa dissolved in 200 mL semi-skimmed milk | food | 13 | Healthy; 3 M; 10 F; Age= 29.6 ± 4.2 y; BMI 22.9 ± 0.6 kg/m² | 94,35 mg | Single | 3,40±3,3 (SD) | 0,6±1,4 (SD) | 1,8 | (0-8h) | Publications |