Intervention Studies for the metabolite 3,3′-Diindolylmethane with food phytochemical Indole-3-carbinol
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indole-3-carbinol | 3,3′-Diindolylmethane | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 21 | Obese ;21 M; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.4129 nmol/mg creatinine (day 0); 0.7186 nmol/mg creatinine (day 35); 0.3547 nmol/mg creatinine (day 50); 0.4516 nmol/mg creatinine (day 85)±0.0011-0.0056 nmol/mg creatinine (day 0); 0.2539-0.5478nmol/mg creatinine (day 35);0.0005-0.0091nmol/mg creatinine (day 50); 0.0017-0.0151 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Indole-3-carbinol | 3,3′-Diindolylmethane | Human | Urine | Host metabolism | The treatment were applied during 10 weeks (70 days) and samples were taken on day 0 and 70 and after the treatment on day 90 and 160) | Food | 40 | Obese; Age= 35-55 Y; BMI= 24.9- 29.9 kg/m² | 30 g/ day | Multiple | 70 days | 0.484 µM (day 0); 0.707 µM(day 70); 0.449 µM (day 90); 0.461 µM (day 160)±0.38-0.59 µM (day 0); 0.61-0.8 µM(day 70); 0.33-0.57 µM (day 90); 0.36-0.56 µM (day 160) (CI) | Publications | ||||||||
| Indole-3-carbinol | 3,3′-Diindolylmethane | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 19 | Obese;19 non-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0663 nmol/mg creatinine (day 0); 0.4989 nmol/mg creatinine (day 35); 0.0027 nmol/mg creatinine (day 50); 0.0128 nmol/mg creatinine (day 85)±0.1291-0.801 nmol/mg creatinine (day 0); 0.5029-0.8521 nmol/mg creatinine (day 35); 0.1147-0.4704 nmol/mg creatinine (day 50); 0.1799-1.1452 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Indole-3-carbinol | 3,3′-Diindolylmethane | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 19 | Obese;19 post-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0656 nmol/mg creatinine (day 0); 1.8191 nmol/mg creatinine (day 35); 0.0135 nmol/mg creatinine (day 50); 0.004 nmol/mg creatinine (day 85)±0.0044-0.0876 nmol/mg creatinine (day 0); 0.116-2.2411 nmol/mg creatinine (day 35); 0.0022-0.0179 nmol/mg creatinine (day 50); 0.0029-0.0048 nmol/mg creatinine (day 85) (CI) | Publications |