Intervention Studies for the metabolite Curcumin glucuronide with food phytochemical Curcumin

Food Phytochemical	Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	Publications
Curcumin	Curcumin glucuronide	Human	Plasma	Host metabolism	500 mg of Cureit™ in capsule with 240 mL water	pure compound	15	Healthy, BMI 18.5-24.9 kg/m2	232,5 mg	Single	2,5	0,86	3,2	(0-24h)	0,301	Publications
Curcumin	Curcumin glucuronide	Human	Plasma	Host metabolism	liquid droplet micromicellar formulation (400 mg)	pure compound	12	Healthy, 6 M/6 F, age M (28.7 ± 7.7 y), age F (29.8 ± 6.7 y). BMI M (24.8 ± 3.1 kg/m2), BMI F (23.6 ± 3.4 kg/m2)	76 mg	Single	1,6±0,11 (SEM)	300,0			0,005	Publications
Curcumin	Curcumin glucuronide	Human	Plasma	Host metabolism	unformulated 95% curcumin capsules (400 mg)	pure compound	12	Healthy, 6 M/6 F, age M (28.7 ± 7.7 y), age F (29.8 ± 6.7 y). BMI M (24.8 ± 3.1 kg/m2), BMI F (23.6 ± 3.4 kg/m2)	380 mg	Single	4±0 (SEM)	1,0			2,3	Publications
Curcumin	Curcumin glucuronide	Human	Serum	Host metabolism	bread + free curcumin (1g)	food	10	Healthy, age 31 ± 2 y; BMI 23.5 ± 1.2 kg/m2	3000 µmol	Single	2	0,06±0,04 (SEM)	0,1	(0-6h)		Publications
Curcumin	Curcumin glucuronide	Human	Serum	Host metabolism	bread + encapsulated curcumin (1g)	food	10	Healthy, age 31 ± 2 y; BMI 23.5 ± 1.2 kg/m2	3000 µmol	Single	1	0,13±0,05 (SEM)	0,2	(0-6h)		Publications
Curcumin	Curcumin glucuronide	Human	Serum	Host metabolism	bread + encapsulated curcumin (1g) + polyphenols	food	10	Healthy, age 31 ± 2 y; BMI 23.5 ± 1.2 kg/m2	3000 µmol	Single	1	0,35±0,25 (SEM)	0,33	(0-6h)		Publications