Intervention Studies for the metabolite Phloretin with food phytochemical Apple dihydrochalcones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Apple dihydrochalcones | Phloretin | Human | Ileal fluid | Unchanged/ host metabolism | 500 mL of Thatchers Redstreak cider | food | 5 | Ilestomy; Age= 40-54; BMI=26 kg/m² | 46±0.3 μmol DHC µmol | Single | 24h | Publications | |||||||||
| Apple dihydrochalcones | Phloretin | Human | Urine | Host metabolism | Two bags of lyophilized Golden Delicious apples per day suspendend in half glass of water | food | 30 | Healthy; 30M; Age= 52.6±5.5 ; BMI=25.7±2.6kg/m² | Phloridzin 8.8mg; Phloretin xyloglucoside 5.8mg | Multiple | 4.2±0.3 weeks | Publications | |||||||||
| Apple dihydrochalcones | Phloretin | Human | Urine | Host metabolism | Two bags of lyophilized Marie Ménard apples per day suspendend in half glass of water | food | 30 | Healthy; 30 M; Age= 52.6±5.5 ; BMI=25.7±2.6kg/m² | Phloridzin 11.2mg; Phloretin xyloglucoside 13.8 mg | Multiple | 4.3±0.9 weeks | Publications | |||||||||
| Apple dihydrochalcones | Phloretin | Human | Ileal fluid | Host metabolism | 1.1L of alcoholic cider | food | 6 | Healthy; Age=24-42 Y; BMI:21.1-29.3Kg/m² | Phloretin xyloglucoside 1.5mg; Phlorizin3.1 mg; Phloretin 0.19mg | Single | 24h | 21±5 (SD) | 3.8±1±1 µmol (SD) (0-24h) | Publications | |||||||
| Apple dihydrochalcones | Phloretin | Human | Ileal fluid | Unknown | 500 mL of Thatchers Redstreak cider | food | 5 | Ilestomy; Age= 40-54; BMI=26 kg/m² | 46±0.3 μmol DHC µmol | Single | 24h | Publications |