Intervention Studies for the metabolite Phloretin-glucuronide with food phytochemical Apple dihydrochalcones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Apple dihydrochalcones | Phloretin-glucuronide | Human | Urine | Host metabolism | 500 mL of Thatchers Redstreak cider | food | 9 | Healthy; Age= 21-24 ; BMI= 26.1 | 46±0.3 μmol DHC µmol | Single | 24 h | 0.47 | 216±53 nmol (SD) (0-24h) | Publications | |||||||
| Apple dihydrochalcones | Phloretin-glucuronide | Human | Urine; Illeal fluid | Host metabolism | 500 mL of Thatchers Redstreak cider | food | 5 | Ilestomy;Age= 40-54; BMI= 28 | 46±0.3 μmol DHC µmol | Single | 24 h | 0.77 | 353nmol±57 at (SD) (0-24h) | Publications | |||||||
| Apple dihydrochalcones | Phloretin-glucuronide | Human | Plasma | Host metabolism | 80 g of red fleshed apple snack | food | 10 | Healthy; 5M;5F; Age=37.3±8.4; BMI= 18.5-24.9kg/m² | 33.7 mg : Phloretin glucoside 21.7 ± 2.54mg; Phloretin xylosyl glucoside 11.7 ± 0.52mg; Hydroxyphloretin xylosyl glucoside 0.32 ± 0.03mg | Single | 24 h | 2 | 61±6.82 (SD) | Publications | |||||||
| Apple dihydrochalcones | Phloretin-glucuronide | Human | Urine | Host metabolism | 80 g of red fleshed apple snack | food | 10 | Healthy; 5M;5F; Age=37.3±8.4; BMI= 18.5-24.9kg/m² | 33.7 mg : Phloretin glucoside 21.7 ± 2.54mg; Phloretin xylosyl glucoside 11.7 ± 0.52mg; Hydroxyphloretin xylosyl glucoside 0.32 ± 0.03mg | Single | 24 h | Publications |