Intervention Studies for the metabolite 2-methyl-3-(3'-3'-carboxymethylpropyl)-1,4-naphthoquinone with food phytochemical Phylloquinone
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phylloquinone | 2-methyl-3-(3'-3'-carboxymethylpropyl)-1,4-naphthoquinone | Human | Urine | Host metabolism | Phylloquinone (Sigma Chemical) was added to corn oil in muffins, which were given to subjects as part of their breakfast meal | pure compound | 8 | Healthy; 4M;4F; Age=27-39 | 11 µg/day | Single | 15 days | 74.1 | 2.89µg/day±1.1 (SEM) | Publications | |||||||
| Phylloquinone | 2-methyl-3-(3'-3'-carboxymethylpropyl)-1,4-naphthoquinone | Human | Urine | Host metabolism | Phylloquinone (Sigma Chemical) was added to corn oil in muffins, which were given to subjects as part of their breakfast meal | pure compound | 8 | Healthy; 4M;4F; Age=27-39 | 206 µg/day | Single | 24h | 56.78 | 6.23µg/day±0.77 (SEM) | Publications | |||||||
| Phylloquinone | 2-methyl-3-(3'-3'-carboxymethylpropyl)-1,4-naphthoquinone | Human | Urine | Host metabolism | Phylloquinone (Sigma Chemical) was added to corn oil in muffins, which were given to subjects as part of their breakfast meal | pure compound | 8 | Healthy; 4M;4F; Age=27-39 | 93.1 µg/day | Multiple | 5 days | 74.4 | 3.55µg/day±0.55 (SEM) | Publications | |||||||
| Phylloquinone | 2-methyl-3-(3'-3'-carboxymethylpropyl)-1,4-naphthoquinone | Human | Urine | Host metabolism | Phylloquinone (Sigma Chemical) was added to corn oil in muffins, which were given to subjects as part of their breakfast meal | pure compound | 8 | Healthy; 4M;4F; Age=27-39 | 206 µg/day | Multiple | 10 days | 77.3 | 8.48µg/day±0.87 (SEM) | Publications |