Intervention Studies for the metabolite 1-methylxanthine with food phytochemical Caffeine
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | NoDoz® caplets + 180 mL water | pure compound | 15 | 200 mg | Single | 7,60 | 15.2mg±5,9 (0-24 (SD) (h)) | Publications | |||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | gelatin capsules with water | pure compound | 107 | Healthy; 52 M; 55 F; Age= 22 ± 3 y; Spanish | 300 mg | Single | 9,13±0,4 (SEM) | Publications | |||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | pure compound | 5 | Healthy; 4 F; 1 M; Nonsmokers; Age= 25±1 y | 0,004 g/Kg bw | Single | 11,40±1,4 (SEM) | Publications | ||||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | 70 mL of acqueous solution | pure compound | 4 | Healthy;M; Age= 26-36 y | 350 mg | Single | 12,80±2,3 (SEM) | Publications | |||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 7 | Healthy; age 22.2±4.0 y; caucasians | 0,005 g/Kg bw | Single | 9,48±3,7 (SD) | Publications | |||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | dissolved in water | pure compound | 68 | Healthy; 35 M; 33 F; Age= 26.6 y ; 42 Caucasians; 26 Oriental | 300 mg | Single | 10,10±4,1 (SD) | Publications | |||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 5 | Healthy; Age= 69.6±2.3 y; caucasians | 0,005 g/Kg bw | Single | 8,90±5,43 (SD) | Publications | |||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | pure compound | 5 | Healthy; 4 F; 1 M; Smokers; Age= 30±9 y | 0,004 g/Kg bw | Single | 18,70±6,9 (SEM) | Publications | ||||||||||
| Caffeine | 1-methylxanthine | Human | Urine | Host metabolism | tablets | pure compound | 8 | Healthy; M; Age= 27 y | 200 mg | Single | 6,10 | Publications |