Intervention Studies for the metabolite Naringenin-4',5-diglucuronide with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Naringenin-4',5-diglucuronide | Human | Urine | Host metabolism | 524 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.12 (SEM) | 0.09±0.08 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-4',5-diglucuronide | Human | Urine | Host metabolism | 525 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.05 (SEM) | 0.04±0.04 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-4',5-diglucuronide | Human | Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Naringenin-4',5-diglucuronide | Human | Urine | Host metabolism | 524 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.12±0.08 (SEM) | 0.09±0.06 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-4',5-diglucuronide | Human | Urine | Host metabolism | 525 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.05±0.04 (SEM) | 0.04±0.03 µmol (SEM) (0-24h) | Publications |