Intervention Studies for the metabolite Hesperetin-3',7-diglucuronide with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Plasma | Host metabolism | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 6.6±0.4 (SEM) | 1.3±0.4 (SEM) | 6.4 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Urine | Host metabolism | 512 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.008 (SEM) | 0.02±0.008 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Urine | Host metabolism | 512 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.008 (SEM) | 0.02±0.008 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Plasma and Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy, M, Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 2.84 | 9.9 | Publications | |||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Plasma | Host metabolism | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 6.6±0.4 (SEM) | 1.3±0.4 (SEM) | 6.4 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy, M, Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 2,844827586 | 9,9±3,4 | Publications | |||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Urine | Host metabolism | 512 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.008±0.008 (SEM) | 0.02±0.02 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3',7-diglucuronide | Human | Urine | Host metabolism | 512 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.008±0.008 (SEM) | 0.02±0.02 µmol (SEM) (0-24h) | Publications |