Intervention Studies for the metabolite Hesperetin-3',7-diglucuronide with food phytochemical Orange flavanones

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Plasma	Host metabolism	500 mL Orange juice (Tropicana with bits)	food	10	Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2	330 μmol flavanones µmol	Single		6.6±0.4 (SEM)	1.3±0.4 (SEM)	6.4	0-8 h				Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Urine	Host metabolism	512 mL Orange juice (Tropicana with bits)	food	10	Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week	330 µmol flavanones	Single							0.008 (SEM)	0.02±0.008 µmol (SEM) (0-24h)	Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Urine	Host metabolism	512 mL Orange juice (Tropicana with bits)	food	10	Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days	330 µmol flavanones	Single							0.008 (SEM)	0.02±0.008 µmol (SEM) (0-24h)	Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Plasma and Urine	Host-gut microbiota co-metabolite	500 ml of orange juice	food	12	Healthy, M, Age=31.8±5.7; BMI=21.7±1.8kg/m²	250µmol of hesperetin derivatives and 75µmol of naringenin derivatives	Single	24h								Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Urine	Host-gut microbiota co-metabolite	250 ml pulp enriched orange juice	food	12	Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m²	537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)]	Single	24h						2.84	9.9	Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Plasma	Host metabolism	500 mL Orange juice (Tropicana with bits)	food	10	Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2	330 μmol flavanones µmol	Single		6.6±0.4 (SEM)	1.3±0.4 (SEM)	6.4	0-8 h				Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Plasma; Urine	Host-gut microbiota co-metabolite	500 ml of orange juice	food	12	Healthy, M, Age=31.8±5.7; BMI=21.7±1.8kg/m²	250µmol of hesperetin derivatives and 75µmol of naringenin derivatives	Single	24h								Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Urine	Host-gut microbiota co-metabolite	250 ml pulp enriched orange juice	food	12	Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m²	537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)]	Single	24h						2,844827586	9,9±3,4	Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Urine	Host metabolism	512 mL Orange juice (Tropicana with bits)	food	10	Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week	330 µmol flavanones	Single							0.008±0.008 (SEM)	0.02±0.02 µmol (SEM) (0-24h)	Publications
	Orange flavanones		Hesperetin-3',7-diglucuronide	Human	Urine	Host metabolism	512 mL Orange juice (Tropicana with bits)	food	10	Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days	330 µmol flavanones	Single							0.008±0.008 (SEM)	0.02±0.02 µmol (SEM) (0-24h)	Publications

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