Intervention Studies for the metabolite Hesperetin-diglucuronide with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 mL orange Juice: Citrus sinensis | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 502.7± 20.7 µmol flavanones | Single | 5.2±0.8 (SEM) | 18±4 (SEM) | 44 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 mL orange Juice: Citrus sinensis | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 502.7± 20.7 µmol flavanones | Single | 4.8±0.7 (SEM) | 8±2 (SEM) | 22 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 ml fermented orange Juice | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 667.2±31.6 µmol flavanones | Single | 4.6±0.6 (SEM) | 29±8 (SEM) | 81 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 ml fermented orange Juice | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 667.2±31.6 µmol flavanones | Single | 5.3±0.4 (SEM) | 8±2 (SEM) | 22 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54.09 μmol | Single | 0.73 | 395.3 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 0.4 (SD) | 767±0.3 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 ml fermented orange Juice | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 667.2±31.6 µmol flavanones | Single | 5.3±0.4 (SEM) | 8±2 (SEM) | 22 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 mL orange Juice: Citrus sinensis | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 502.7± 20.7 µmol flavanones | Single | 4.8±0.7 (SEM) | 8±2 (SEM) | 22 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 mL orange Juice: Citrus sinensis | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 502.7± 20.7 µmol flavanones | Single | 5.2±0.8 (SEM) | 18±4 (SEM) | 44 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Plasma | Host metabolism | 500 ml fermented orange Juice | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 667.2±31.6 µmol flavanones | Single | 4.6±0.6 (SEM) | 29±8 (SEM) | 81 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54,09 µmol | Single | 0,73 | 395.3 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 0,4±0,3 (SD) | 767±361 nmol (SD) (0-24h) | Publications |