Intervention Studies for the metabolite 5-(3',4'-dihydroxyphenyl)-γ-valerolactone with food phytochemical Red Grape pomace Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Red Grape pomace Flavan-3-ols | 5-(3',4'-dihydroxyphenyl)-γ-valerolactone | Human | Plasma; Urine | Gut microbiota metabolite | 250 mL of red grape pomace aqueous extract | Extract | 10 | Healthy; 10 M; Age=26±2 y; BMI=27±3 kg/m2 | 983.47 µmol | Single | 7±2 (SEM) | 14,3±3,2 (SEM) | 66,1 | (0-24h) | 39,50±26,4 (SEM) | 0,06710931701 | 0.66±0,09 µmol (SEM) ((0-48h)) | Publications | |||
| Red Grape pomace Flavan-3-ols | 5-(3',4'-dihydroxyphenyl)-γ-valerolactone | Human | Urine | Gut microbiota metabolite | 100 mL of dealcoholised red wine + grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 76.9±24,8 µmol (SD) ((0-24h)) | Publications | |||||||||
| Red Grape pomace Flavan-3-ols | 5-(3',4'-dihydroxyphenyl)-γ-valerolactone | Human | Urine | Gut microbiota metabolite | 100 mL of dealcoholised red wine + encapsulated grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 71.8±29,5 µmol (SD) ((0-24h)) | Publications |