Intervention Studies for the metabolite 5-(Hydroxyphenyl)-γ-valerolactone-sulfate with food phytochemical Cocoa Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | cocoa-based products containing coffee | Food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 15,6 µmol | Multiple | 1 month (twice daily) | 5,9±1,1 (SEM) | 87,3±17,7 (SEM) | 452,9 | (0-24h) | 70.86±16,62 µmol (SEM) ((0-24h)) | Publications |