Intervention Studies for the metabolite 5-(3'-hydroxyphenyl)-γ-valerolactone-4'-sulfate with food phytochemical Cocoa Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa Flavan-3-ols | 5-(3'-hydroxyphenyl)-γ-valerolactone-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 15 g of cocoa + 200 mL of milk | Food | 13 | Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2 | 68.2 µmol | Single | 5,3±2,4 (SD) | 0,336±0,24 (SD) | 1,15 | (0-8h) | 14,5542522 | 9.926±3,2 µmol (SD) ((0-24h)) | Publications | ||||
| Cocoa Flavan-3-ols | 5-(3'-hydroxyphenyl)-γ-valerolactone-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 25 g of flavanol-rich cocoa + 200 mL of milk | Food | 13 | Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2 | 235.1 µmol | Single | 4,9±1,2 (SD) | 0,332±0,161 (SD) | 1,384 | (0-8h) | 13,32113994 | 31.318±6,822 µmol (SD) ((0-24h)) | Publications |