Intervention Studies for the metabolite (-)-Epicatechin 3'-O-glucuronide with food phytochemical Cocoa Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-glucuronide | Human | Urine | Host metabolism | 40 g cocoa powder + 250 mL whole milk | Food | 21 | Healthy; 9 F; 12 M; Age=25±7; BMI=21.59±2.1 kg/m2 | 62.1 mg | Single | 0,227966712 | 0.38 µmol ((0-24h)) | Publications | ||||||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-glucuronide | Human | Urine | Host metabolism | 40 g of cocoa powder + 250 mL water | Food | 21 | Healthy; 9 F; 12 M; Age=25±7; BMI=21.59±2.1 kg/m2 | 62.1 mg | Single | 0,3383593466 | 0.57 µmol ((0-24h)) | Publications | ||||||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-glucuronide | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2 | 400 mg | Single | 1,1±0,1 (SEM) | 309±41 (SEM) | 805 | (0-6h) | 1,90±0,1 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-glucuronide | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2 | 400 mg | Single | 1,3±0,1 (SEM) | 371±34 (SEM) | 1089 | (0-6h) | 2,20±0,1 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-glucuronide | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2 | 800 mg | Single | 1,2±0,1 (SEM) | 551±67 (SEM) | 1532 | (0-6h) | 1,70±0,1 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-glucuronide | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2 | 800 mg | Single | 1,2±0,1 (SEM) | 645±66 (SEM) | 2015 | (0-6h) | 2,30±0,1 (SEM) | Publications |