Intervention Studies for the metabolite (-)-Epicatechin 3'-O-glucuronide with food phytochemical Cocoa Flavan-3-ols

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Cocoa Flavan-3-ols		(-)-Epicatechin 3'-O-glucuronide	Human	Urine	Host metabolism	40 g cocoa powder + 250 mL whole milk	Food	21	Healthy; 9 F; 12 M; Age=25±7; BMI=21.59±2.1 kg/m2	62.1 mg	Single							0,227966712	0.38 µmol ((0-24h))	Publications
	Cocoa Flavan-3-ols		(-)-Epicatechin 3'-O-glucuronide	Human	Urine	Host metabolism	40 g of cocoa powder + 250 mL water	Food	21	Healthy; 9 F; 12 M; Age=25±7; BMI=21.59±2.1 kg/m2	62.1 mg	Single							0,3383593466	0.57 µmol ((0-24h))	Publications
	Cocoa Flavan-3-ols		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	500 mL of cocoa powder drink	Food	20	Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2	400 mg	Single		1,1±0,1 (SEM)	309±41 (SEM)	805	(0-6h)	1,90±0,1 (SEM)			Publications
	Cocoa Flavan-3-ols		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	500 mL of cocoa powder drink	Food	20	Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2	400 mg	Single		1,3±0,1 (SEM)	371±34 (SEM)	1089	(0-6h)	2,20±0,1 (SEM)			Publications
	Cocoa Flavan-3-ols		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	500 mL of cocoa powder drink	Food	20	Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2	800 mg	Single		1,2±0,1 (SEM)	551±67 (SEM)	1532	(0-6h)	1,70±0,1 (SEM)			Publications
	Cocoa Flavan-3-ols		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	500 mL of cocoa powder drink	Food	20	Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2	800 mg	Single		1,2±0,1 (SEM)	645±66 (SEM)	2015	(0-6h)	2,30±0,1 (SEM)			Publications

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