Intervention Studies for the metabolite (Epi)catechin with food phytochemical Cocoa Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa Flavan-3-ols | (Epi)catechin | Human | Serum | Unchanged | 99 g of cocoa-nut cream + cocoa in encapsulated form | Food | 12 | Healthy; 4 M; 8 F; Age=24±3; BMI=23.1±1.5 kg/m2 | 385,3 µmol | Multiple | 1 dose morning + 1 dose at lunch + 1 dose at dinner | 0,9±0,6 (SEM) | 0,5 | (0-6h) | Publications | ||||||
| Cocoa Flavan-3-ols | (Epi)catechin | Human | Serum; Urine | Unchanged | 99 g of cocoa-nut cream + cocoa in free form | Food | 12 | Healthy; 4 M; 8 F; Age=24±3; BMI=23.1±1.5 kg/m2 | 385,1 µmol | Multiple | 1 dose morning + 1 dose at lunch + 1 dose at dinner | 4,1±2,3 (SEM) | 7,4 | (0-6h) | 0,00181251623 | 6.98 nmol ((0-24h)) | Publications | ||||
| Cocoa Flavan-3-ols | (Epi)catechin | Human | Urine | Unchanged | 99 g of nut cream (20 % of cocoa) | Food | 12 | Healthy; 4 M; 8 F; Age=24±3; BMI=23.1±1.5 kg/m2 | 190 µmol | Multiple | 1 dose morning + 1 dose at lunch + 1 dose at dinner | 0,008952631579 | 17.01 nmol ((0-24h)) | Publications |