Intervention Studies for the metabolite (-)-Epicatechin 3'-O-sulfate with food phytochemical Cocoa Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2 | 400 mg | Single | 1,8±0,2 (SEM) | 98±12 (SEM) | 264 | (0-6h) | 1,20±0,1 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2 | 400 mg | Single | 1,7±0,2 (SEM) | 125±13 (SEM) | 365 | (0-6h) | 2,20±0,2 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2 | 800 mg | Single | 1,5±0,1 (SEM) | 251±20 (SEM) | 682 | (0-6h) | 1,40±0,1 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | (-)-Epicatechin 3'-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2 | 800 mg | Single | 1,7±0,1 (SEM) | 212±13 (SEM) | 654 | (0-6h) | 2,00±0,2 (SEM) | Publications |