Intervention Studies for the metabolite 3'-O-Methyl-(-)-epicatechin 5-O-sulfate with food phytochemical Cocoa Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cocoa Flavan-3-ols | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2 | 400 mg | Single | 1,4±0,1 (SEM) | 7±7 (SEM) | 193 | (0-6h) | 1,80±0,2 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2 | 400 mg | Single | 1,4±0,1 (SEM) | 7±7 (SEM) | 215 | (0-6h) | 2,30±0,3 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=26±6; BMI=24±2 kg/m2 | 800 mg | Single | 1,6±0,1 (SEM) | 176±14 (SEM) | 509 | (0-6h) | 1,90±0,2 (SEM) | Publications | |||||
| Cocoa Flavan-3-ols | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma | Host metabolism | 500 mL of cocoa powder drink | Food | 20 | Healthy; 20 M; Caucasians; Age=70±4; BMI=27±3 kg/m2 | 800 mg | Single | 1,8±0,2 (SEM) | 128±11 (SEM) | 389 | (0-6h) | 1,90±0,2 (SEM) | Publications |