Intervention Studies for the metabolite Feruloylglycine with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Feruloylglycine | Human | Plasma | Host metabolism | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,75 | 0,067±0,04 (SD) | Publications | ||||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Plasma | Host-gut microbiota co-metabolite | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,066±0,029 (SD) | Publications | |||||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 7 ± 2±2 (SD) | 0,02±0,01 (SD) | 0,09 | (0-12h) | 1,84 | 14µmol(0-24h)±4 (SD) (14µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 5,02 | 20.7µmol(0-24h)±3,9 (SEM) (20.7µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4,50 | 18.7µmol(0-24h)±(109.;26.4) (IR) (18.7µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 4,10 | 26.2µmol(0-24h)±(17.5;29.9) (IR) (26.2µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 3,40 | 27.2µmol(0-24h)±(24;38.9) (IR) (27.2µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | Tablets | extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 933,00 µmol | Multiple | 4 weeks (3 doses daily) | 2,82 | 26.3µmol(0-24h)±6,7 (SEM) (26.3µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 2,86 | 5.86µmol(0-24h)±0,84 (SEM) (5.86µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 1,62 | 9.94µmol(0-24h)±1,53 (SEM) (9.94µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 1,77 | 5.23µmol(0-24h)±0,66 (SEM) (5.23µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Feruloylglycine | Human | Urine | Host-gut microbiota co-metabolite | 4 g 'Green Blend' instant Coffee | food | 36 | 882,00 µmol | Single | 5,74 | 50.6µmol(0-36h)±22,9 (SD) (50.6µmol(0-36h)) | Publications |