Intervention Studies for the metabolite Dihydroferulic acid with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma | Host-gut microbiota co-metabolite | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,878±0,635 (SD) | Publications | |||||||||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 6,62 | 449 | 117846 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,23 | 416 | 115718 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 7,88 | 399 | 101955 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4,7±0,3 (SEM) | 385±86 (SEM) | 2333 | (0-24h) | 1,4±0,4 (SEM) | 2,35 | 9.7µmol±2 (0-24h) (SEM) ((0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 6 ± 1±1 (SD) | 0,3±0,1 (SD) | 1,3 | (0-12h) | 1,18 | 9µmol(0-24h)±2 (SD) (9µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4±(4.0;6.0) (IR) | 375±(344;587) (IR) | 2845 | (0-24h) | 2,1±(1.9;2.2) (IR) | 2,10 | 8.7µmol(0-24h)±(41.;15.0) (IR) (8.7µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 5±(4.0;7.5) (IR) | 463±(330;620) (IR) | 3792 | (0-24h) | 2,1±(2.0;2.2) (IR) | 1,50 | 9.2µmol(0-24h)±(7.0;18.9) (IR) (9.2µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 6±(6.0;6.0) (IR) | 518±(462;771) (IR) | 4549 | (0-24h) | 2±(1.8;2.0) (IR) | 1,30 | 10.6µmol(0-24h)±(6;18.7) (IR) (10.6µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid | Human | Urine | Host-gut microbiota co-metabolite | 4 g 'Green Blend' instant Coffee | food | 36 | 882,00 µmol | Single | 1,94 | 17.1±11,3 µmol(0-36h) (SD) (µmol(0-36h)) | Publications |