Intervention Studies for the metabolite Dihydroferulic acid with food phytochemical Coffee Chlorogenic acids

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma	Host-gut microbiota co-metabolite	350 mL of coffee (18.66 g of coffee)	food	13	Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y)	519,07 µmol	Single			0,878±0,635 (SD)						Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma	Host-gut microbiota co-metabolite	200 mL of instant coffee beverage	food	14	Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians	48,03 µmol	Single		6,62	449	117846	(0-15h)				Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma	Host-gut microbiota co-metabolite	200 mL of coffee + 2 bread rolls + honey	food	14	Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians	48,03 µmol	Single		8,23	416	115718	(0-15h)				Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma	Host-gut microbiota co-metabolite	200 mL of coffee + 1 bread roll + peanut butter	food	14	Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians	48,03 µmol	Single		7,88	399	101955	(0-15h)				Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma; Urine	Host-gut microbiota co-metabolite	200 mL of coffee (3.4 g of instant powder)	food	11	Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2	412,00 µmol	Single		4,7±0,3 (SEM)	385±86 (SEM)	2333	(0-24h)	1,4±0,4 (SEM)	2,35	9.7µmol±2 (0-24h) (SEM) ((0-24h))	Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma; Urine	Host-gut microbiota co-metabolite	250 mL of coffee (3.5 g of green-roasted coffee)	food	12	Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2)	760.6 μmol	Single		6 ± 1±1 (SD)	0,3±0,1 (SD)	1,3	(0-12h)		1,18	9µmol(0-24h)±2 (SD) (9µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma; Urine	Host-gut microbiota co-metabolite	200 mL of instant coffee beverage	food	11	healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2	412,00 µmol	Single		4±(4.0;6.0) (IR)	375±(344;587) (IR)	2845	(0-24h)	2,1±(1.9;2.2) (IR)	2,10	8.7µmol(0-24h)±(41.;15.0) (IR) (8.7µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma; Urine	Host-gut microbiota co-metabolite	200 mL of instant coffee beverage	food	11	healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2	635,00 µmol	Single		5±(4.0;7.5) (IR)	463±(330;620) (IR)	3792	(0-24h)	2,1±(2.0;2.2) (IR)	1,50	9.2µmol(0-24h)±(7.0;18.9) (IR) (9.2µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Plasma; Urine	Host-gut microbiota co-metabolite	200 mL of instant coffee beverage	food	11	healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2	795,00 µmol	Single		6±(6.0;6.0) (IR)	518±(462;771) (IR)	4549	(0-24h)	2±(1.8;2.0) (IR)	1,30	10.6µmol(0-24h)±(6;18.7) (IR) (10.6µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Dihydroferulic acid	Human	Urine	Host-gut microbiota co-metabolite	4 g 'Green Blend' instant Coffee	food	36		882,00 µmol	Single							1,94	17.1±11,3 µmol(0-36h) (SD) (µmol(0-36h))	Publications

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