Intervention Studies for the metabolite 3-O-Caffeoylquinic acid with food phytochemical 3-O-Caffeoylquinic acid
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 5,23±0,61 (SEM) | Publications | ||||||||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 4,14±0,52 (SEM) | Publications | ||||||||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Plasma | Unchanged | wild blueberry beverage | food | 12 | Healthy; 6 M; 6 F. Age=29±5 y; BMI=28.8±2.2 kg/m2. 1 Hispanic/african/american mixed; 2 caucasians; 2 hispanic; 2 asian; 5 african/american mixed. | 961,80 µmol | Single | 2,1±0,2 (SEM) | 42,8±5,1 (SEM) | 684 | (0-24h) | Publications | ||||||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 2,2±0,4 (SEM) | 6,5±1 (SEM) | 21,5 | (0-24h) | 0,16 | 0.33±0,03 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 4,5±0,5 (SEM) | 6,8±0,8 (SEM) | 45,6 | (0-24h) | 0,12 | 0.74µmol(0-24h)±0,07 (SEM) (0.74µmol(0-24h)) | Publications | |||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 4,4±0,5 (SEM) | 5,4±0,6 (SEM) | 26,8 | (0-24h) | 0,14 | 0.4µmol(0-24h)±0,05 (SEM) (0.4µmol(0-24h)) | Publications | |||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Serum | Unchanged | 480 mg of green coffee bean extract | extract | 15 | Healthy; M | 290,71 µmol | Single | 1 | 11,4±4,92 (SD) | 27,3 | (0-4h) | Publications | ||||||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Urine | Unchanged | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,01 | 0.044μmol(0-24h)±0,009 (SD) (0.044μmol(0-24h)) | Publications | ||||||||
| 3-O-Caffeoylquinic acid | 3-O-Caffeoylquinic acid | Human | Urine | Unchanged | 4.91 g of yerba mate in 250 mL water | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 1118,00 µmol | Single | 0,02 | 0.211µmol(0-24h)±0,08 (SD) (0.211µmol(0-24h)) | Publications |