Intervention Studies for the metabolite Paraxanthine with food phytochemical Caffeine
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caffeine | Paraxanthine | Human | Urine | Host metabolism | NoDoz® caplets + 180 mL water | pure compound | 15 | 200 mg | Single | 4,38 | 8.75mg±3,07 (0-24h) (SD) ((0-24h)) | Publications | |||||||||
| Caffeine | Paraxanthine | Human | Urine | Host metabolism | gelatin capsules with water | pure compound | 107 | Healthy; 52 M; 55 F; Age= 22 ± 3 y; Spanish | 300 mg | Single | 4,08±0,18 (SEM) | Publications | |||||||||
| Caffeine | Paraxanthine | Human | Urine | Host metabolism | 70 mL of acqueous solution | pure compound | 4 | Healthy;M; Age= 26-36 y | 350 mg | Single | 4,40±1 (SEM) | Publications | |||||||||
| Caffeine | Paraxanthine | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 5 | Healthy; Age= 69.6±2.3 y; caucasians | 0,005 g/Kg bw | Single | 3,37±1,47 (SD) | Publications | |||||||||
| Caffeine | Paraxanthine | Human | Urine | Host metabolism | dissolved in 200 mL water | pure compound | 7 | Healthy; age 22.2±4.0 y; caucasians | 0,005 g/Kg bw | Single | 3,49±1,87 (SD) | Publications | |||||||||
| Caffeine | Paraxanthine | Human | Urine | Host metabolism | dissolved in water | pure compound | 68 | Healthy; 35 M; 33 F; Age= 26.6 y ; 42 Caucasians; 26 Oriental | 300 mg | Single | 4,80±2,4 (SD) | Publications | |||||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | tablets | pure compound | 8 | Healthy; M; Age= 27 y | 200 mg | Single | 2,00 | 8 | 4,10 | Publications | |||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 150 mL water | pure compound | 6 | Healthy; M; heterozygous for the CYP1A2∗1C/∗1F (GA/CA)genotype; Chinese | 100 mg | Single | 5,00±(3.0, 6.0) (CI) | 6,6±(5.7-7.5) (CI) | 91,5 | (0-24h) | 4,9±(4.1-5.7) (CI) | Publications | |||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 150 mL water + multiples doses quercetin capsules | pure compound | 6 | Healthy; M; heterozygous for the CYP1A2∗1C/∗1F (GA/CA)genotype; Chinese | 100 mg | Single | 6,00±(2.0, 10) (CI) | 5,8±(4.5, 7.1) (CI) | 77,9 | (0-24h) | 5,4±(4.8-5.9) (CI) | Publications | |||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 150 mL water | pure compound | 6 | Healthy; M; homozygous for the CYP1A2∗1C/∗1F (GG/AA) genotype; Chinese | 100 mg | Single | 9,00±(2, 12) (CI) | 6,6±(5.4, 7.8) (CI) | 112,4 | (0-24h) | 6,6±(4.9-8.4) (CI) | Publications | |||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 150 mL water + multiples doses quercetin capsules | pure compound | 6 | Healthy; M; homozygous for the CYP1A2∗1C/∗1F (GG/AA) genotype; Chinese | 100 mg | Single | 6,00±(3, 12) (CI) | 5,3±(4.7, 5.8) (CI) | 89,6 | (0-24h) | 8±(6.7-9.2) (CI) | Publications | |||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 200 mL water | pure compound | 12 | Healthy; Age= 18–35 y | 500 mg | Single | 12,89 | (0-8h) | Publications | ||||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 250 mL water | pure compound | 12 | Healthy; 5 M; 7 F; Age= 28.8±6.6 y | 500 mg | Single | 17,3 | (0-8h) | Publications | ||||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 200 mL water | pure compound | 12 | Healthy; Age= 18–35 y | 250 mg | Single | 8,46 | (0-8h) | Publications | ||||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | capsules with 250 mL water | pure compound | 12 | Healthy; 5 M; 7 F; Age= 28.8±6.6 y | 250 mg | Single | 9,43 | (0-8h) | Publications | ||||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | 2 tablets | pure compound | 10 | Healthy; 7 M; 3 F; Age= 35±6 y | 200 mg | Single | 160 | (0-24h) | Publications | ||||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | tablet | pure compound | 30 | Healthy; M; Age= 24.± 4.7 y ; European (15); South Asian (15); BMI= 26.9±3 kg/m² | 100 mg | Single | 6,00 | 0,5±0,1 (SD) | 9,7 | (0-24h) | Publications | ||||||
| Caffeine | Paraxanthine | Human | Plasma | Host metabolism | tablet | pure compound | 30 | Healthy; M; Age= 24.± 4.7 y ; European (15); South Asian (15); BMI= 26.9±3 kg/m² | 100 mg | Single | 6,00 | 0,7 | Publications |