Intervention Studies for the metabolite 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Plasma | Gut microbiota metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 7.5±0.1 (SEM) | 20±2 (SEM) | 57 | 0-8 h | Publications | ||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 5.1 (SEM) | 10±1.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 8.2 (SEM) | 16±3.6 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 562 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 4.6 (SEM) | 18.5±1.4 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 562 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 5.27 (SEM) | 21±1.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml pulp enriched orange juice | food | 9 | Healthy; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 13.4 | 72 | Publications | |||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Plasma; Urine | Gut microbiota metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Plasma | Gut microbiota metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 7.5±0.1 (SEM) | 20±2 (SEM) | 57 | 0-8 h | Publications | ||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml pulp enriched orange juice | food | 9 | Healthy; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 13,4 | 72±10 | Publications | |||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 5.1±1.5 (SEM) | 10±3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 8.2±3.6 (SEM) | 16±7 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 562 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 4.6±1.4 (SEM) | 18.5±5.8 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxy-4'-methoxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 562 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 5.27±1.5 (SEM) | 21±6 µmol (SEM) (0-24h) | Publications |