Intervention Studies for the metabolite 3'-Hydroxyphenylacetic acid with food phytochemical Orange flavanones

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid																		Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Plasma	Gut microbiota metabolite	500 mL Orange juice (Tropicana with bits)	food	10	Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2	330 μmol flavanones µmol	Single		3.1±0.2 (SEM)	34±2 (SEM)	175	0-8 h				Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Urine	Gut microbiota metabolite	548 mL Orange juice (Tropicana with bits)	food	10	Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days	330 µmol flavanones	Single							0.43 (SEM)	1.7±0.14 µmol (SEM) (0-24h)	Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Plasma; Urine	Gut microbiota metabolite	500 ml of orange juice	food	12	Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m²	250µmol of hesperetin derivatives and 75µmol of naringenin derivatives	Single	24h								Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Urine	Gut microbiota metabolite	250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside	food	5	Healthy;Age=21-50; BMI=19.9-27.2kg/m²	168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside	Single	24h						4.05	7.3 µmol (0-24h)	Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Urine	Gut microbiota metabolite	250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside and 150mL of natural yoghurt	food	5	Healthy;Age=21-50; BMI=19.9-27.2kg/m²	168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside	Single	24h						2.16	3.9 µmol (0-24h)	Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Plasma	Gut microbiota metabolite	500 mL Orange juice (Tropicana with bits)	food	10	Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2	330 μmol flavanones µmol	Single		3.1±0.2 (SEM)	34±2 (SEM)	175	0-8 h				Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Urine	Gut microbiota metabolite	250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside	food	5	Healthy;Age=21-50; BMI=19.9-27.2kg/m²	168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside	Single	24h						4,05	7.3±3 µmol (0-24h)	Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Urine	Gut microbiota metabolite	250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside and 150mL of natural yoghurt	food	5	Healthy;Age=21-50; BMI=19.9-27.2kg/m²	168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside	Single	24h						2,16	3.9±2,6 µmol (0-24h)	Publications
	Orange flavanones		3'-Hydroxyphenylacetic acid	Human	Urine	Gut microbiota metabolite	548 mL Orange juice (Tropicana with bits)	food	10	Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days	330 µmol flavanones	Single							0.43±0.14 (SEM)	1.7±0.6 µmol (SEM) (0-24h)	Publications

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