Intervention Studies for the metabolite 3-(3'-Hydroxyphenyl)hydracrylic acid with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Plasma | Gut microbiota metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 3.5±0.2 (SEM) | 628±18 (SEM) | 3202 | 0-8 h | Publications | ||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 400 g orange fruit | food | 11 | Healthy; Age= 28; BMI= 23.2±1.8 kg/m² | 1477 µmol | Single | 24 hours | 21.6 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 719 g pasteurized orange juice | food | 11 | Healthy; Age=28; BMI =23.2±1.8 kg/m² | 636 µmol | Single | 24 hours | 18.3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 8.7 (SEM) | 17±2 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 7.1 (SEM) | 14±2 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml pulp enriched orange juice | food | 8 | Healthy; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 31 | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Plasma; Urine | Gut microbiota metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 5 | Healthy;Age=21-50; BMI=19.9-27.2kg/m² | 168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside | Single | 24h | 17.2 µmol (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside and 150mL of natural yoghurt | food | 5 | Healthy;Age=21-50; BMI=19.9-27.2kg/m² | 168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside | Single | 24h | 1.2 at (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Plasma | Gut microbiota metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 3.5±0.2 (SEM) | 628±18 (SEM) | 3202 | 0-8 h | Publications | ||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 5 | Healthy;Age=21-50; BMI=19.9-27.2kg/m² | 168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside | Single | 24h | 17.2±4,2 µmol (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside and 150mL of natural yoghurt | food | 5 | Healthy;Age=21-50; BMI=19.9-27.2kg/m² | 168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside | Single | 24h | 1.2±0,6 at (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 250 ml pulp enriched orange juice | food | 8 | Healthy; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 31±4 | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 8.7±2 (SEM) | 17±4 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 7.1±2 (SEM) | 14±8 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 400 g orange fruit | food | 11 | Healthy; Age= 28; BMI= 23.2±1.8 kg/m² | 1477 µmol | Single | 24 hours | 21.6±8 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3-(3'-Hydroxyphenyl)hydracrylic acid | Human | Urine | Gut microbiota metabolite | 719 g pasteurized orange juice | food | 11 | Healthy; Age=28; BMI =23.2±1.8 kg/m² | 636 µmol | Single | 24 hours | 18.3±7,2 µmol (SEM) (0-24h) | Publications |