Intervention Studies for the metabolite Hesperetin with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin | Publications | |||||||||||||||||||
| Orange flavanones | Hesperetin | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice | food | 4 | Healthy ; 2 M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54.09 μmol | Single | 0.01 | 6.5 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 g orange fruit | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 1477 µmol | Single | 24 hours | 1.5 | 21.6 µmol (SEM) (0.9-93.6µmol)) | Publications | |||||||
| Orange flavanones | Hesperetin | Human | Urine | Gut microbiota metabolite | 719 g pasteurized orange juice | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 636 µmol | Single | 24 hours | 2.9 | 18.3 µmol (SEM) (1.6-78.5µmol)) | Publications | |||||||
| Orange flavanones | Hesperetin | Human | Plasma and Urine | Gut microbiota metabolite | 300g of orange juice | food | 20 | Healthy; 10M;10F; Age=49±11; BMI=24.8±3 kg/m² | 71 mg | Single | 6.2±2.04 (SD) | 30.9±38 (SD) | 346 | 0-∞ | 4.63 | Publications | |||||
| Orange flavanones | Hesperetin | Human | Plasma and Urine | Gut microbiota metabolite | 150 g of fresh orange segments | food | 20 | Healthy; 10M;10F; Age=49±11; BMI=24.8±3 kg/m² | 79.7 mg | Single | 7±4.23 (SD) | 28.8±37.3 (SD) | 376 | 0-∞ | 4.53 | Publications | |||||
| Orange flavanones | Hesperetin | Human | Plasma | Host-gut microbiota co-metabolite | 400 mL of orange juice containing 116mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 116 mg of flavanones ( 7.2 mg of Narngenin-7-rut-4'-glc; 3.6 mg of Hesperetin-7-rut-3'glc; 19.2 mg Naringenin-7-rut; 67.2mg hesperedin; 4.4 mg didymin) | Multiple | 5 weeks | 4.6±0.7 (SD) | 324.5±65.1 (SD) | 1184 | 0-24h | 5.4 (SD) | 9,0±1.2 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Hesperetin | Human | Plasma | Host-gut microbiota co-metabolite | 400 mL of orange juice containing 197.6 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 197.6 mg of flavanones ( 8.8 mg of Narngenin-7-rut-4'-glc; 4.4mg of Hesperetin-7-rut-3'-glc; 24.88 mg Naringenin-7-rut; 152 mg hesperedin ; 7.6 mg didymin) | Multiple | 5 weeks | 6.4±0.7 (SD) | 366±69.8 (SD) | 945.6 | 0-24h | 1.7 (SD) | 5,7±0.4 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Hesperetin | Human | Plasma | Host-gut microbiota co-metabolite | 400 mL of puplp enriched orange juice containing 274 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 274 mg of flavanones ( 12.4mg of Narngenin-7-rut-4'-glc; 5.2 mg of Hesperetin-7-rut-3'-glc; 25.2 mg Naringenin-7-rut; 218 mg hesperedin ; 8.8 mg didymin) | Multiple | 5 weeks | 6±0.7 (SD) | 151.5±25.7 (SD) | 503.6 | 0-24h | 1 (SD) | 4,7±0.5 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Hesperetin | Human | Plasma; Urine | Gut microbiota metabolite | 300g of orange juice | food | 20 | Healthy; 10M;10F; Age=49±11; BMI=24.8±3 kg/m² | 71 mg | Single | 6,2±2,04 (SD) | 30,9±38 (SD) | 346 | 0-∞ | 4,63 | Publications | |||||
| Orange flavanones | Hesperetin | Human | Plasma | Host-gut microbiota co-metabolite | 400 mL of orange juice containing 116mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 116 mg of flavanones ( 7.2 mg of Narngenin-7-rut-4'-glc; 3.6 mg of Hesperetin-7-rut-3'glc; 19.2 mg Naringenin-7-rut; 67.2mg hesperedin; 4.4 mg didymin) | Multiple | 5 weeks | 4,6±0,7 (SD) | 324,5±65,1 (SD) | 1184 | 0-24h | 5,4±1,2 (SD) | 9,0±2,1 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Hesperetin | Human | Plasma; Urine | Gut microbiota metabolite | 150 g of fresh orange segments | food | 20 | Healthy; 10M;10F; Age=49±11; BMI=24.8±3 kg/m² | 79,7 mg | Single | 7±4,23 (SD) | 28,8±37,3 (SD) | 376 | 0-∞ | 4,53 | Publications | |||||
| Orange flavanones | Hesperetin | Human | Plasma | Host-gut microbiota co-metabolite | 400 mL of puplp enriched orange juice containing 274 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 274 mg of flavanones ( 12.4mg of Narngenin-7-rut-4'-glc; 5.2 mg of Hesperetin-7-rut-3'-glc; 25.2 mg Naringenin-7-rut; 218 mg hesperedin ; 8.8 mg didymin) | Multiple | 5 weeks | 6±0,7 (SD) | 151,5±25,7 (SD) | 503,6 | 0-24h | 1±0,5 (SD) | 4,7±2,2 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Hesperetin | Human | Plasma | Host-gut microbiota co-metabolite | 400 mL of orange juice containing 197.6 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 197.6 mg of flavanones ( 8.8 mg of Narngenin-7-rut-4'-glc; 4.4mg of Hesperetin-7-rut-3'-glc; 24.88 mg Naringenin-7-rut; 152 mg hesperedin ; 7.6 mg didymin) | Multiple | 5 weeks | 6,4±0,7 (SD) | 366±69,8 (SD) | 945,6 | 0-24h | 1,7±0,4 (SD) | 5,7±1,5 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Hesperetin | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice | food | 4 | Healthy ; 2 M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54,09 µmol | Single | 0,01 | 6.5 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin | Human | Urine | Gut microbiota metabolite | 400 g orange fruit | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 1477 µmol | Single | 24 hours | 1.5 | 21.6±8 µmol (SEM) (0.9-93.6µmol)) | Publications | |||||||
| Orange flavanones | Hesperetin | Human | Urine | Gut microbiota metabolite | 719 g pasteurized orange juice | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 636 µmol | Single | 24 hours | 2.9 | 18.3±7,2 µmol (SEM) (1.6-78.5µmol)) | Publications |