Intervention Studies for the metabolite Dihydroisoferulic acid with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Dihydroisoferulic acid | Human | Plasma | Gut microbiota metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 7.3±0.1 (SEM) | 19±1 (SEM) | 59 | 0-8 h | Publications | ||||||
| Orange flavanones | Dihydroisoferulic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 2.3 (SEM) | 4.6±0.3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Dihydroisoferulic acid | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Dihydroisoferulic acid | Human | Plasma | Gut microbiota metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 7.3±0.1 (SEM) | 19±1 (SEM) | 59 | 0-8 h | Publications | ||||||
| Orange flavanones | Dihydroisoferulic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 2.3±0.3 (SEM) | 4.6±0.7 µmol (SEM) (0-24h) | Publications |