Intervention Studies for the metabolite 3-methoxy-aspalathin-glucuronide with food phytochemical Aspalathin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Human | Urine | Host metabolism | 300 mL of dried green rooibos leaves infusion | food | 6 | Healthy; 2M;2F, Age=26.2 Y; BMI= 19-27 kg/m² | 91.2 mg | Single | 24 h | Publications | |||||||||
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Human | Urine | Host metabolism | 500 ml of unfermented rooibos tea | food | 10 | Healthy; 5M;5F | 90 µmol | Single | 24 h | 0.25 | 229±26 nmol (SEM) (0-24h) | Publications | |||||||
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Human | Urine | Host metabolism | 500 ml of fermented rooibos tea | food | 10 | Healthy; 5M;5F | 8 µmol | Single | 24 h | 0.125 | 10nmol±2 at (SEM) (0-24h) | Publications | |||||||
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Human | Urine | Host metabolism | 500 mL rooibos drink | food | 12 | Healthy; 12M; Age=25.3Y; BMI=23.4kg/m² | 636 ± 20 µmol | Single | 24 h | Publications | |||||||||
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Human | Urine | Host metabolism | 500 mL of the highest antioxidant fraction in rooibos drink | food | 12 | Healthy; 12M; Age=25.3Y; BMI=23.4kg/m² | 636 ± 20 µmol | Single | 24 h | Publications | |||||||||
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Pig | Urine | Host metabolism | 96 g Aspalathin-enriched green rooibos extract mixed with feed | extract | 3 | Pig; 3F; Age=6M;BW=94-99 kg | 0.157– 0.168 g/Kg bw | Multiple | 11 days | Publications | |||||||||
| Aspalathin | 3-methoxy-aspalathin-glucuronide | Human | Urine | Host metabolism | 500 ml of fermented rooibos tea | food | 10 | Healthy; 5M;5F | 8 µmol | Single | 24 h | 0.125 | 10±2 nmol (SEM) (0-24h) | Publications |