Intervention Studies for the metabolite Hesperetin-3'-sulfate with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 4.26 (SEM) | 7.2 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 6.44 (SEM) | 10.9 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Plasma | Host metabolism | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 5.9±0.4 (SEM) | 80±24 (SEM) | 280 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 502 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.51 (SEM) | 1.7 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 503 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.72 (SEM) | 2.4 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy ; 2 M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54.09 μmol | Single | 0.35 | 189 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 5.23 | 18.2 | Publications | |||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Plasma; Urine | Host metabolism | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Plasma | Host metabolism | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 5.9±0.4 (SEM) | 80±24 (SEM) | 280 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 5,229885057 | 18,2±7,3 | Publications | |||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 4,26 (SEM) | 7.2±0.7 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 6,44 (SEM) | 10.9±1.2 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 502 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0,51 (SEM) | 1.7±1.0 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 503 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0,72 (SEM) | 2.4±1.3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-3'-sulfate | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy ; 2 M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54,09 µmol | Single | 0,35 | 189 nmol (SD) (0-24h) | Publications |