Intervention Studies for the metabolite Naringenin-diglucuronide with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 1.25 (SEM) | 0.7±0.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 1.25 (SEM) | 0.7±0.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 31.39 μmol | Single | 0.6 (SD) | 177.2±0.001844536477 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 0.9 (SD) | 98±0.4 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 1.52 | 2.5 | Publications | |||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 1,515151515 | 2,5±0,7 | Publications | |||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 1.25±0.5 (SEM) | 0.7±0,3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 1.25±0.5 (SEM) | 0.7±0,3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 31,39 µmol | Single | 0,6±0,001844536477 (SD) | 177.2 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin-diglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 0,9±0,4 (SD) | 98±46 nmol (SD) (0-24h) | Publications |