Intervention Studies for the metabolite 3'-Methoxy-4'-hydroxyphenylacetic acid with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 0.9 (SEM) | 1.9±0.6 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Gut microbiota metabolite | 250 ml pulp enriched orange juice | food | 6 | Healthy; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 7.3 µmol (0-24h) | Publications | ||||||||
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Host-gut microbiota co-metabolite | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 5 | Healthy;Age=21-50; BMI=19.9-27.2kg/m² | 168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside | Single | 24h | 11.7 µmol (0-24h) | Publications | ||||||||
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Host-gut microbiota co-metabolite | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 5 | Healthy;Age=21-50; BMI=19.9-27.2kg/m² | 168µmol of hesperetin-7-o-rutinoside and 12µmol of naringenin-7-o-rutinoside | Single | 24h | 11.7±2,6 µmol (0-24h) | Publications | ||||||||
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Gut microbiota metabolite | 250 ml pulp enriched orange juice | food | 6 | Healthy; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 7.3±0,8 µmol (0-24h) | Publications | ||||||||
| Orange flavanones | 3'-Methoxy-4'-hydroxyphenylacetic acid | Human | Urine | Gut microbiota metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18- 35 kg/m2 | 169 µl flavanones µmol | Single | 0.9±0.6 (SEM) | 1.9±1.1 µmol (SEM) (0-24h) | Publications |