Intervention Studies for the metabolite Naringenin with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Naringenin | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 31.39 μmol | Single | 0.18 (SD) | 55.2±0.0004 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 150ml blood orange juice (51.3±0.8 mg Hesperetin; 5.9±0.2 mg Naringenin) | food | 7 | Healthy; 7F; Age=25.7±1.1 ; BMI=16.2-21.8 kg/m² | 51.3±0.8 mg Hesperetin; 5.9±0.2 mg Naringenin | Single | 5±0.6 (SD) | 16.4±11.9 (SD) | 9 | 0-∞ | Publications | ||||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 300ml blood orange juice (102.4±1.8 mg Hesperetin; 11.8±0.4 mg Naringenin) | food | 7 | Healthy; 7F; Age=25.7±1.1; BMI=16.2-21.8 kg/m² | 102.4±1.8 mg Hesperetin; 11.8±0.4 mg Naringenin | Single | 5±0 (SD) | 34±20.6 (SD) | 8 | 0-∞ | Publications | ||||||
| Orange flavanones | Naringenin | Human | Urine | Gut microbiota metabolite | 400 g orange fruit | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 1477 µmol | Single | 24 hours | 12.9 | 38.3 µmol (SEM) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Gut microbiota metabolite | 719 g pasteurized orange juice | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 636 µmol | Single | 24 hours | 20.3 | 23.3 µmol (SEM) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Plasma and Urine | Gut microbiota metabolite | 150 g of fresh orange segments | food | 20 | Healthy; 10M;10F; Age=49±11 ; BMI=24.8±3 kg/m² | 11.8 mg | Single | 5.88±1.83 (SD) | 23±32.1 (SD) | 230 | 0-∞ | 12.5 | Publications | |||||
| Orange flavanones | Naringenin | Human | Plasma and Urine | Gut microbiota metabolite | 300g of orange juice | food | 20 | Healthy; 10M;10F; Age=49±11 ; BMI=24.8±3 kg/m² | 9.4 mg | Single | 4.46±2.56 (SD) | 14.3±14.4 (SD) | 176 | 0-∞ | 10.2 | Publications | |||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 400 mL of orange juice containing 116mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 116 mg of flavanones ( 7.2 mg of Narngenin-7-rut-4'-glc; 3.6 mg of Hesperetin-7-rut-3'glc; 19.2 mg Naringenin-7-rut; 67.2mg hesperedin; 4.4 mg didymin) | Multiple | 5 weeks | 4.7±1.1 (SD) | 37±10.1 (SD) | 66.7 | 0-24h | 2.6 (SD) | 4,8±0.5 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 400 mL of orange juice containing 197.6 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 197.6 mg of flavanones ( 8.8 mg of Narngenin-7-rut-4'-glc; 4.4mg of Hesperetin-7-rut-3'-glc; 24.88 mg Naringenin-7-rut; 152 mg hesperedin ; 7.6 mg didymin) | Multiple | 5 weeks | 5.7±0.7 (SD) | 443.5±109.3 (SD) | 735.2 | 0-24h | 0.7 (SD) | 2,6±0.2 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 400 mL of puplp enriched orange juice containing 274 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 274 mg of flavanones ( 12.4mg of Narngenin-7-rut-4'-glc; 5.2 mg of Hesperetin-7-rut-3'-glc; 25.2 mg Naringenin-7-rut; 218 mg hesperedin ; 8.8 mg didymin) | Multiple | 5 weeks | 5±0.6 (SD) | 67.3±7.1 (SD) | 200.6 | 0-24h | 0.5 (SD) | 2,3±0.2 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Naringenin | Human | Serum | Unchanged | Naringenin capsules | pure compound | 16 | 6M; 10F; Age= 20-50 | 150 mg | Multiple | 3 weeks | 3.2±0.7 (SD) | 15.8±7.9 (SD) | 67.6 | 0-24h | Publications | |||||
| Orange flavanones | Naringenin | Human | Serum | Unchanged | Naringenin capsules | pure compound | 16 | 6M; 10F; Age= 20-50 | 600 mg | Multiple | 3 weeks | 2.4±0.7 (SD) | 48.5±7.9 (SD) | 199.1 | 0-24h | Publications | |||||
| Orange flavanones | Naringenin | Human | Urine | Host metabolism | 400 mL of fresh orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 7 mg of ( Naringenin-7-rutinoside-4'-glucoside, Naringenin-7-rutinoside, Naringenin-4'-methyl-7-rutinoside) | Multiple | 3 weeks | 11 (SD) | 0,8±1.8 mg (SD) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Host metabolism | 400 mL of high pressure homogenized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 21.9 mg of ( Naringenin-7-rutinoside-4'-glucoside, Naringenin-7-rutinoside, Naringenin-4'-methyl-7-rutinoside) | Multiple | 3 weeks | 7.7 (SD) | 1,7±1.9 mg (SD) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Host metabolism | 400 mL of pasteurized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 22.5 mg of ( Naringenin-7-rutinoside-4'-glucoside, Naringenin-7-rutinoside, Naringenin-4'-methyl-7-rutinoside) | Multiple | 3 weeks | 6.7 (SD) | 1,5±1.2 mg (SD) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Plasma; Urine | Gut microbiota metabolite | 300g of orange juice | food | 20 | Healthy; 10M;10F; Age=49±11 ; BMI=24.8±3 kg/m² | 9,4 mg | Single | 4,46±2,56 (SD) | 14,3±14,4 (SD) | 176 | 0-∞ | 10,2 | Publications | |||||
| Orange flavanones | Naringenin | Human | Plasma; Urine | Gut microbiota metabolite | 150 g of fresh orange segments | food | 20 | Healthy; 10M;10F; Age=49±11 ; BMI=24.8±3 kg/m² | 11,8 mg | Single | 5,88±1,83 (SD) | 23±32,1 (SD) | 230 | 0-∞ | 12,5 | Publications | |||||
| Orange flavanones | Naringenin | Human | Serum | Unchanged | Naringenin capsules | pure compound | 16 | 6M; 10F; Age= 20-50 | 600 mg | Multiple | 3 weeks | 2,4±0,7 (SD) | 48,5±7,9 (SD) | 199,1 | 0-24h | Publications | |||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 400 mL of puplp enriched orange juice containing 274 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 274 mg of flavanones ( 12.4mg of Narngenin-7-rut-4'-glc; 5.2 mg of Hesperetin-7-rut-3'-glc; 25.2 mg Naringenin-7-rut; 218 mg hesperedin ; 8.8 mg didymin) | Multiple | 5 weeks | 5±0,6 (SD) | 67,3±7,1 (SD) | 200,6 | 0-24h | 0,5±0,2 (SD) | 2,3±1,2 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 300ml blood orange juice (102.4±1.8 mg Hesperetin; 11.8±0.4 mg Naringenin) | food | 7 | Healthy; 7F; Age=25.7±1.1; BMI=16.2-21.8 kg/m² | 102.4±1.8 mg Hesperetin; 11.8±0.4 mg Naringenin | Single | 5±0 (SD) | 34±20,6 (SD) | 8 | 0-∞ | Publications | ||||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 150ml blood orange juice (51.3±0.8 mg Hesperetin; 5.9±0.2 mg Naringenin) | food | 7 | Healthy; 7F; Age=25.7±1.1 ; BMI=16.2-21.8 kg/m² | 51.3±0.8 mg Hesperetin; 5.9±0.2 mg Naringenin | Single | 5±0,6 (SD) | 16,4±11,9 (SD) | 9 | 0-∞ | Publications | ||||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 400 mL of orange juice containing 116mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 116 mg of flavanones ( 7.2 mg of Narngenin-7-rut-4'-glc; 3.6 mg of Hesperetin-7-rut-3'glc; 19.2 mg Naringenin-7-rut; 67.2mg hesperedin; 4.4 mg didymin) | Multiple | 5 weeks | 4,7±1,1 (SD) | 37±10,1 (SD) | 66,7 | 0-24h | 2,6±0,5 (SD) | 4,8±0,9 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Naringenin | Human | Serum | Unchanged | Naringenin capsules | pure compound | 16 | 6M; 10F; Age= 20-50 | 150 mg | Multiple | 3 weeks | 3,2±0,7 (SD) | 15,8±7,9 (SD) | 67,6 | 0-24h | Publications | |||||
| Orange flavanones | Naringenin | Human | Plasma | Gut microbiota metabolite | 400 mL of orange juice containing 197.6 mg of flavanones | food | 10 | Healthy; 5M;5F; Age= 20-30 | 197.6 mg of flavanones ( 8.8 mg of Narngenin-7-rut-4'-glc; 4.4mg of Hesperetin-7-rut-3'-glc; 24.88 mg Naringenin-7-rut; 152 mg hesperedin ; 7.6 mg didymin) | Multiple | 5 weeks | 5,7±0,7 (SD) | 443,5±109,3 (SD) | 735,2 | 0-24h | 0,7±0,2 (SD) | 2,6±0,8 µmol (SD) (0-24h) | Publications | |||
| Orange flavanones | Naringenin | Human | Urine | Gut microbiota metabolite | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 31,39 µmol | Single | 0,18±0,0004 (SD) | 55.2±13 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Naringenin | Human | Urine | Gut microbiota metabolite | 400 g orange fruit | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 1477 µmol | Single | 24 hours | 12.9 | 38.3±10,2 µmol (SEM) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Gut microbiota metabolite | 719 g pasteurized orange juice | food | 11 | Healthy; Age =28; BMI= 23.2±1.8kg/m² | 636 µmol | Single | 24 hours | 20.3 | 23.3±7,5 µmol (SEM) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Host metabolism | 400 mL of fresh orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 7 mg of ( Naringenin-7-rutinoside-4'-glucoside, Naringenin-7-rutinoside, Naringenin-4'-methyl-7-rutinoside) | Multiple | 3 weeks | 11±1,8 (SD) | 0,8±0,1 mg (SD) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Host metabolism | 400 mL of high pressure homogenized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 21.9 mg of ( Naringenin-7-rutinoside-4'-glucoside, Naringenin-7-rutinoside, Naringenin-4'-methyl-7-rutinoside) | Multiple | 3 weeks | 7,7±1,9 (SD) | 1,7±0,4 mg (SD) (0-24h) | Publications | |||||||
| Orange flavanones | Naringenin | Human | Urine | Host metabolism | 400 mL of pasteurized orange Juice | food | 18 | 10M; 8F; Age= 20-50 | 22.5 mg of ( Naringenin-7-rutinoside-4'-glucoside, Naringenin-7-rutinoside, Naringenin-4'-methyl-7-rutinoside) | Multiple | 3 weeks | 6,7±1,2 (SD) | 1,5±0,3 mg (SD) (0-24h) | Publications |