Intervention Studies for the metabolite Ferulic acid-4'-sulfate with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 1.2±0.2 (SEM) | 19±2 (SEM) | 61 | 0-8 h | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 536 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 1.9 (SEM) | 7.8±0.6 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 537 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 1.48 (SEM) | 5.9±0.52 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 mL orange Juice: Citrus sinensis | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 502.7± 20.7 µmol flavanones | Single | 1.8±0.4 (SEM) | 158±23 (SEM) | 400 | 0-8 h | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 ml fermented orange Juice | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 667.2±31.6 µmol flavanones | Single | 1.4±0.2 (SEM) | 179±18 (SEM) | 472 | 0-8 h | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 mL orange Juice: Citrus sinensis | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 502.7± 20.7 µmol flavanones | Single | 1.8±0.4 (SEM) | 158±23 (SEM) | 400 | 0-8 h | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 ml fermented orange Juice | food | 9 | Healthy;2M; 7F; Age= 21 -25; BMI= 21.1 ± 2.4 kg/m² | 667.2±31.6 µmol flavanones | Single | 1.4±0.2 (SEM) | 179±18 (SEM) | 472 | 0-8 h | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 1.2±0.2 (SEM) | 19±2 (SEM) | 61 | 0-8 h | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 536 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 1.9±0.6 (SEM) | 7.8±2.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 537 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 1.48±0.52 (SEM) | 5.9±2.1 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 500 mL of orange juice | food | 10 | Healthy; M; BMI= 21.7±0.6 kg/m2 | 330,00 µmol | Single | 1,2±0,2 (SEM) | 19±2 (SEM) | 61 | (0-24h) | Publications | ||||||
| Orange flavanones | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 500 mL of orange juice | food | 10 | Healthy; M; BMI= 21.7±0.6 kg/m2 | 330,00 µmol | Single | 1,79 | 5.92µmol(0-24h)±2,1 (SEM) (5.92µmol(0-24h)) | Publications |