Intervention Studies for the metabolite Hesperetin-5-sulfate with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin-5-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 6.5±0.3 (SEM) | 3.3±0.7 (SEM) | 10 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.08 (SEM) | 0.2±0-04 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 501 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.08 (SEM) | 0.2±0.08 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Plasma and Urine | Host-gut microbiota co-metabolite | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 5.2±1.2 (SD) | 6.6±2.4 (SD) | 15 | 0-∞ | 404.2 nmol (SD) (0-24h) | Publications | |||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 162.3 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Plasma and Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 6.5±0.3 (SEM) | 3.3±0.7 (SEM) | 10 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 5,2±1,2 (SD) | 6,6±2,4 (SD) | 15 | 0-∞ | 404.2±75,3 nmol (SD) (0-24h) | Publications | |||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.08±0-04 (SEM) | 0.2±0.1 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 501 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.08±0.08 (SEM) | 0.2±0.2 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin-5-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 162.3±29,5 nmol (SD) (0-24h) | Publications |