Intervention Studies for the metabolite (-)-Epigallocatechin 3-O-gallate with food phytochemical (-)-Epigallocatechin 3-O-gallate
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 400 mL of green tea | Food | 5 | 403,9 µmol | Single | 79,9±25,4 (SD) | Publications | ||||||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 300 mg of Teavigo (2 capsules) + 100 mL of water | Extract | 5 | Healthy; 5 M; Age=30.6±5.2 y; BMI=23.7±2.8 kg/m2 | 140 mg | Single | 2 | 528,6±472,3 (SEM) | 2,57 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 300 mg of Teavigo (2 capsules) + 100 mL of water | Extract | 5 | Healthy; 5 F; Age=28.8±3.6 y; BMI=19.9±2.1 kg/m2 | 140 mg | Single | 1,5 | 466,1±116,3 (SEM) | 1,95 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 300 mg of Teavigo (2 capsules) + 100 mL of water + standardized breakfast | Extract | 5 | Healthy; 5 M; Age=30.6±5.2 y; BMI=23.7±2.8 kg/m2 | 140 mg | Single | 2 | 275,3±89,1 (SEM) | 1,55 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 300 mg of Teavigo (2 capsules) + 100 mL of water + standardized breakfast | Extract | 5 | Healthy; 5 F; Age=28.8±3.6 y; BMI=19.9±2.1 kg/m2 | 140 mg | Single | 3 | 318,7±147 (SEM) | 1,86 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 266 mg of FontUp supplement + 200 mL of semi-skimmed milk | Extract | 5 | Healthy; 5 M; Age=30.6±5.2 y; BMI=23.7±2.8 kg/m2 | 250 mg | Single | 1,5 | 63,7±7,7 (SEM) | 3,20 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 266 mg of FontUp supplement + 200 mL of semi-skimmed milk | Extract | 5 | Healthy; 5 F; Age=28.8±3.6 y; BMI=19.9±2.1 kg/m2 | 250 mg | Single | 2 | 94,5±24,5 (SEM) | 2,22 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 330 mL of drink | Extract | 12 | Healthy; 12 M; Age=21±2 y; BMI=24.2±1.9 kg/m2 | 1118.4 mg | Multiple | 1 day (1 dose morning + 1 dose evening) | 126±40 (SD) | 17241 | (0-3h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 330 mL of drink | Extract | 13 | Healthy; 13 M; Age=22±5 y; BMI=24.3±3.0 kg/m2 | 1118.4 mg | Multiple | 7 days (1 dose morning + 1 dose evening) | 141±45 (SD) | 18368 | (0-3h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 2 capsules (2 × 250 mg) + 100 mL of water | Pure compound | 4 | Healthy; 3 M; 1 F; Age=31.25 ± 9.54; BMI=23.1 kg/m2 | 500 mg | Single | 1 | 824,2±75,1 (SD) | 1,31±1,31 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 2 capsules (2 × 250 mg) + 50 g breakfast cereals + 200 mL of milk | Pure compound | 4 | Healthy; 3 M; 1 F; Age=31.25 ± 9.54; BMI=23.1 kg/m2 | 500 mg | Single | 2 | 231,8±134,3 (SD) | 2,27±2,27 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | EGCG (500 mg) + 200 g of strawberry sorbet | Pure compound | 4 | Healthy; 3 M; 1 F; Age=31.25 ± 9.54; BMI=23.1 kg/m2 | 500 mg | Single | 2 | 218±160 (SD) | 3,81±3,81 | Publications | |||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Extract | 9 | Healthy; Age=28.67±6.30 y | 200 mg | Single | 2±1,2 (SD) | 327,4±170,2 (SEM) | 1222 | (0-24h) | 2,30±0,5 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Extract | 9 | Healthy; Age=28.67±6.30 y | 200 mg | Multiple | 10 days (once daily) | 1,6±0,7 (SD) | 259,5±63,5 (SEM) | 1107,5 | (0-24h) | 2,40±0,4 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Extract | 9 | Healthy; Age=28.67±6.30 y | 400 mg | Single | 1,6±0,7 (SD) | 504±197,2 (SEM) | 1979,9 | (0-24h) | 2,60±0,7 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Extract | 9 | Healthy; Age=28.67±6.30 y | 400 mg | Multiple | 10 days (once daily) | 1,8±0,7 (SD) | 704,5±723,7 (SEM) | 2447,4 | (0-24h) | 4,10±1,5 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Extract | 9 | Healthy; Age=27.11±5.71 y | 800 mg | Single | 1,9±0,7 (SD) | 2268,8±2113,1 (SEM) | 5799,7 | (0-24h) | 4,10±0,8 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Extract | 9 | Healthy; Age=27.11±5.71 y | 800 mg | Multiple | 10 days (once daily) | 1,8±0,56 (SD) | 2800,2±1552,5 (SEM) | 9032,1 | (0-24h) | 5,00±0,7 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Pure compound | 8 | 50 mg | Single | 1,25±42,76 (CV) | 119,83±24,56 (CV) | 405,74 | (0-inf) | 1,87±22,87 (CV) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Pure compound | 8 | 100 mg | Single | 1,94±42,38 (CV) | 189,52±72,47 (CV) | 1330,89 | (0-inf) | 2,73±91,13 (CV) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Pure compound | 8 | 200 mg | Single | 1,31±28,34 (CV) | 310,28±45,3 (CV) | 50,85 | (0-inf) | 1,90±24,49 (CV) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Pure compound | 8 | 400 mg | Single | 1,44±47,17 (CV) | 568,12±38,96 (CV) | 53,92 | (0-inf) | 3,08±34,92 (CV) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Pure compound | 8 | 800 mg | Single | 1,81±38,84 (CV) | 963,61±33,96 (CV) | 38,98 | (0-inf) | 4,37±21,59 (CV) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules + 400 mL water | Pure compound | 8 | 1600 mg | Single | 1,44±47,17 (CV) | 2911,35±31,85 (CV) | 53,53 | (0-inf) | 4,58±13,75 (CV) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 1 g capsules | Extract | 5 | Healthy; 3 M; 2 F; Age=30.6±11.97 y | 420 mg | Single | 4 | 237,92±4,94 (SEM) | 1147,8 | (0-8h) | 3,27±0,38 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 1 g capsules + nutrient mixture | Extract | 5 | Healthy; 3 M; 2 F; Age=30.6±11.97 y | 420 mg | Single | 4 | 271,24±6,29 (SEM) | 1310 | (0-8h) | 3,41±0,39 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 1 g capsules + 250 mL fresh black grapes | Extract | 5 | Healthy; 3 M; 2 F; Age=30.6±11.97 y | 420 mg | Single | 4 | 328,72±10,63 (SEM) | 1456,8 | (0-8h) | 2,28±0,2 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 190 mL of canned tea beverage | Food | 4 | Healthy; Age=21-28 y | 95 mg | Single | 1,5 | 120 | 857 | (0-8h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 190 mL of canned tea beverage + 40 mg caffeine | Food | 4 | Healthy; Age=21-28 y | 95 mg | Single | 1,5 | 210 | 1370 | (0-8h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 190 mL of canned tea beverage + 180 mg caffeine | Food | 4 | Healthy; Age=21-28 y | 95 mg | Single | 1,5 | 150 | 1165 | (0-8h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 375 mg of Sunphenon BG-5 + 200 mL of water | Extract | 5 | Healthy; 5 F; Age=22 y; BMI=16.2–20.2 kg/m2 | 714 µmol | Single | 1,5 | 0,2 | Publications | ||||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 375 mg of Sunphenon BG-5 + 200 mL of water + 20 g chocolate | Extract | 5 | Healthy; 5 F; Age=22 y; BMI=16.2–20.2 kg/m2 | 729 µmol | Single | 1,5 | 0,12 | Publications | ||||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | green tea decaffeinated extract | Extract | 6 | Healthy; Age=22±2 y | 400 mg | Single | 2 | 0,8 | Publications | ||||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | green tea decaffeinated extract as phospholipid complex | Extract | 6 | Healthy; Age=22±2 y | 400 mg | Single | 2 | 1,8 | Publications | ||||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | NADOLOL (30 mg) + acqueous solution GTE (54 mg in 300 mL) | Food | 13 | Healthy; 2 M; Age=31.0±2.8 y; BMI=26.0±3.0 kg/m2 | 49,95 mg | Single | 1 | 57,4±24,4 (SD) | 128 | (0-4h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | NADOLOL (30 mg) + acqueous solution GTE (162 mg in 300 mL) | Food | 13 | Healthy; 2 M; Age=31.0±2.8 y; BMI=26.0±3.0 kg/m2 | 149,85 mg | Single | 1 | 124,1±60,4 (SD) | 238,3 | (0-4h) | Publications | ||||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of EGCG + water | Pure compound | 5 | Healthy; Age ≥ 30 y | 200 mg | Single | 2,118333333 | 73,7±25,3 (SD) | 22,5 | (0-24h) | 1,97 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of Polyphenon E | Extract | 5 | Healthy; Age ≥ 30 y | 268 mg | Single | 2,411666667 | 72,7±66,4 (SD) | 21,9 | (0-24h) | 2,62 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of EGCG + water | Pure compound | 5 | Healthy; Age ≥ 30 y | 400 mg | Single | 1,811666667 | 111,8±98,6 (SD) | 35,4 | (0-24h) | 2,71 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of Polyphenon E | Extract | 5 | Healthy; Age ≥ 30 y | 536 mg | Single | 2,848333333 | 125,3±50,4 (SD) | 52,2 | (0-24h) | 3,01 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of EGCG + water | Pure compound | 5 | Healthy; Age ≥ 30 y | 600 mg | Single | 3 | 169,1±139,6 (SD) | 101,9 | (0-24h) | 3,06 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of Polyphenon E | Extract | 5 | Healthy; Age ≥ 30 y | 804 mg | Single | 3,6 | 165,7±126,9 (SD) | 79,7 | (0-24h) | 2,72 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of EGCG + water | Pure compound | 5 | Healthy; Age ≥ 30 y | 800 mg | Single | 4,01 | 438,5±284,4 (SD) | 167,1 | (0-24h) | 1,90 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsules of Polyphenon E | Extract | 5 | Healthy; Age ≥ 30 y | 1072 mg | Single | 4,15 | 377,6±149,8 (SD) | 161,4 | (0-24h) | 1,89 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule | Pure compound | 8 | Healthy;2 M; 6 F; Age=39.5±10.4 | 800 mg | Single | 3,74 | 234,9±140,9 (SD) | 95,6 | (0-inf) | 2,27 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule | Pure compound | 8 | Healthy;2 M; 6 F; Age=39.5±10.4 | 800 mg | Multiple | 1 per day for 4 weeks | 3,5 | 390,3±231,4 (SD) | 145,6 | (0-inf) | 2,64 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule of Polyphenon E | Extract | 8 | Healthy;3 M; 5 F; Age=32.4±10.1 | 800 mg | Single | 1,875 | 263,8±135,7 (SD) | 98,1 | (0-inf) | 3,34 | Publications | |||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule of Polyphenon E | Extract | 8 | Healthy;3 M; 5 F; Age=32.4±10.1 | 800 mg | Multiple | 1 per day for 4 weeks | 4,141666667 | 287,6±124,2 (SD) | 158,4 | (0-inf) | 2,71 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule | Pure compound | 8 | Healthy;4 M; 4 F; Age=29.4±10.7 | 800 mg | Multiple | 1 day (1 dose morning + 1 dose evening) | 3,065 | 137,6±66,5 (SD) | 46,9 | (0-inf) | 3,05 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule | Pure compound | 8 | Healthy;4 M; 4 F; Age=29.4±10.7 | 800 mg | Multiple | 2 dose per day for 4 weeks | 2,26 | 161,4±100,5 (SD) | 43,9 | (0-inf) | 2,84 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule of Polyphenon E | Extract | 8 | Healthy; 2 M; 6 F; Age=34.1±11.9 | 800 mg | Multiple | 1 day (1 dose morning + 1 dose evening) | 2,513333333 | 179,9±114,3 (SD) | 71,2 | (0-inf) | 4,02 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | capsule of Polyphenon E | Extract | 8 | Healthy; 2 M; 6 F; Age=34.1±11.9 | 800 mg | Multiple | 2 dose per day for 4 weeks | 2,443333333 | 155,4±61,9 (SD) | 54,8 | (0-inf) | 4,94 | Publications | ||||
| (-)-Epigallocatechin 3-O-gallate | (-)-Epigallocatechin 3-O-gallate | Human | Plasma | Unchanged | 500 mL of Choladi green tea | Food | 10 | 648 µmol | Single | 1,9±0,1 (SEM) | 55±12 (SEM) | 0,17 | (0-24 h) | 1,00 | Publications |