Intervention Studies for the metabolite Hesperetin glucuronide with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µl flavanones µmol | Single | 3.7 (SEM) | 4.1±0.4 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µl flavanones µmol | Single | 3.6 (SEM) | 4.0±0.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 7.1 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 7.7 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 4.1 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4M;4F; Age=21-50; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 2.3 (SD) | 3662±0.3 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 1.4 (SD) | 2319±0.3 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 350 mL Orange juice with 1 g B. longum R0175 | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µl flavanones µmol | Single | 3.7±0.4 (SEM) | 4.1±0.4 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µl flavanones µmol | Single | 3.6±0.5 (SEM) | 4.0±0.5 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 7.1±2,4 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 7.7±1,7 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 4.1±0,7 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4M;4F; Age=21-50; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 2,3±0,3 (SD) | 3662±1483 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin glucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 1,4±0,3 (SD) | 2319±420 nmol (SD) (0-24h) | Publications |