Intervention Studies for the metabolite Hesperetin sulfoglucuronide with food phytochemical Orange flavanones
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 1.26 (SEM) | 1.26±0.3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma | Host metabolism | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 6.3±0.3 (SEM) | 11±2 (SEM) | 35 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 516 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.03 (SEM) | 0.08±0.01 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 517 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.04 (SEM) | 0.11±0.02 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54.09 μmol | Single | 4.73 | 2556 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma and Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 4.3±1.4 (SD) | 2.2±1.1 (SD) | 25.3 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma and Urine | Host metabolism | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 5±1.9 (SD) | 2.2±0.2 (SD) | 33.6 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma and Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 5.2±0.8 (SD) | 21.5±16 (SD) | 95.59 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 72.2 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma and Urine | Host metabolism | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 4.3±1 (SD) | 7±4.5 (SD) | 36.6 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 1.7 (SD) | 2841nmol±0.4 at (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 2.21 | 7.7 | Publications | |||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma and Urine | Host metabolism | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma; Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 4,3±1,4 (SD) | 2,2±1,1 (SD) | 25,3 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma; Urine | Host metabolism | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 5±1,9 (SD) | 2,2±0,2 (SD) | 33,6 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma; Urine | Host metabolism | 786±135 mL of fresh squeezed orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinoside | Single | 4,3±1 (SD) | 7±4,5 (SD) | 36,6 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma | Host metabolism | 500 mL Orange juice (Tropicana with bits) | food | 10 | Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2 | 330 μmol flavanones µmol | Single | 6.3±0.3 (SEM) | 11±2 (SEM) | 35 | 0-8 h | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma; Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 5,2±0,8 (SD) | 21,5±16 (SD) | 95,59 | 0-∞ | Publications | ||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Plasma; Urine | Host metabolism | 500 ml of orange juice | food | 12 | Healthy; M; Age=31.8±5.7; BMI=21.7±1.8kg/m² | 250µmol of hesperetin derivatives and 75µmol of naringenin derivatives | Single | 24h | Publications | |||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 250 ml pulp enriched orange juice | food | 12 | Healthy; 6M;6F; Age=23-60;BMI=23.9- 37.2 kg/m² | 537 µmol flavanones [naringenin-7-O-rutinoside (114 µmol), hesperetin-7-O-rutinoside (329 µmol), didymin(19 µmol), naringenin-7-O-rutinoside-4'-O-glucoside (51 µmol); hesperetin-7-O-rutinoside-3'-Oglucoside (19 µmol), eriodictyol-7-O-rutinoside (5 µmol)] | Single | 24h | 2,212643678 | 7,7±2,6 | Publications | |||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 350 mL Orange juice (after 1 g B. longum R0175 1 month) | food | 15 | Healthy; BMI= 18-35 kg/m² | 169 µmol flavanones | Single | 1.26±0.3 (SEM) | 1.26±0.3 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 516 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week | 330 µmol flavanones | Single | 0.03±0.01 (SEM) | 0.08±0.04 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 517 mL Orange juice (Tropicana with bits) | food | 10 | Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days | 330 µmol flavanones | Single | 0.04±0.02 (SEM) | 0.11±0.06 µmol (SEM) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice | food | 4 | Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m² | 54,09 µmol | Single | 4,73 | 2556 nmol (SD) (0-24h) | Publications | ||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 786± 135mL of pasteurized orange juice | food | 24 | Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m² | 28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinoside | Single | 72.2±24,2 nmol (SD) (0-24h) | Publications | |||||||||
| Orange flavanones | Hesperetin sulfoglucuronide | Human | Urine | Host metabolism | 250 ml of orange juice enriched with 131µmol of hesperetin-7-rutinoside | food | 8 | Healthy ; 4 M; 4F; Age=21-50 ; BMI=22.6 kg/m² | Hesperetin (168 µmol ) ; Naringenin-7-rutinoside (12µmol) | Single | 1,7±0,4 (SD) | 2841nmol±699 at (SD) (0-24h) | Publications |