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Version 1.4

Intervention Studies for the metabolite Hesperetin sulfoglucuronide with food phytochemical Orange flavanones

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Food PhytochemicalMetaboliteSpeciesBiofluidsOriginDietary Source DescriptionDietary Source ClassificationTotal Number of SubjectsDescription of PopulationIngested AmountSingle/Multiple DoseDuration of the StudyTmax (h)Cmax (nM)AUC (nM/h)Time covered by AUC (h)t 1/2 (h)% of 24h Urinary ExcretionExcreted Amount & Time IntervalPublications
Food Phytochemical
Metabolite
Species
Biofluids
Origin
Dietary Source Description
Dietary Source Classification
Total Number of Subjects
Description of Population
Ingested Amount
Single/Multiple Dose
Duration of the Study
Tmax (h)
Cmax (nM)
AUC (nM/h)
Time covered by AUC (h)
t 1/2 (h)
% of 24h Urinary Excretion
Excreted Amount & Time Interval
Publications
Orange flavanones Hesperetin sulfoglucuronideHumanUrineHost metabolism350 mL Orange juice (after 1 g B. longum R0175 1 month)food15Healthy; BMI= 18-35 kg/m²169 µmol flavanonesSingle1.26 (SEM)1.26±0.3 µmol (SEM) (0-24h) Publications
Orange flavanones Hesperetin sulfoglucuronideHumanPlasmaHost metabolism500 mL Orange juice (Tropicana with bits)food10Endurance trained; M; Age= 31.8 ± 5.7; BMI= 21.7 ± 1.8 kg/m2330 μmol flavanones µmolSingle6.3±0.3 (SEM)11±2 (SEM)350-8 h Publications
Orange flavanones Hesperetin sulfoglucuronideHumanUrineHost metabolism516 mL Orange juice (Tropicana with bits)food10Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; performed 5-10 h endurance training per week330 µmol flavanonesSingle0.03 (SEM)0.08±0.01 µmol (SEM) (0-24h) Publications
Orange flavanones Hesperetin sulfoglucuronideHumanUrineHost metabolism517 mL Orange juice (Tropicana with bits)food10Endurance-trained; M; BMI= 21.7 ± 0.6 kg/m²; stoping training for 7 days330 µmol flavanonesSingle0.04 (SEM)0.11±0.02 µmol (SEM) (0-24h) Publications
Orange flavanones Hesperetin sulfoglucuronideHumanUrineHost metabolism250 ml of orange juicefood4Healthy; 2M;2F; Age=23-30 ; BMI= 19.9-23.5kg/m²54.09 μmolSingle4.73 2556 nmol (SD) (0-24h) Publications
Orange flavanones Hesperetin sulfoglucuronideHumanPlasma and UrineHost metabolism786± 135mL of pasteurized orange juicefood24Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m²28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinosideSingle4.3±1.4 (SD)2.2±1.1 (SD)25.30-∞ Publications
Orange flavanones Hesperetin sulfoglucuronideHumanPlasma and UrineHost metabolism786±135 mL of fresh squeezed orange juicefood24Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m²4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinosideSingle5±1.9 (SD)2.2±0.2 (SD)33.60-∞ Publications
Orange flavanones Hesperetin sulfoglucuronideHumanPlasma and UrineHost metabolism786± 135mL of pasteurized orange juicefood24Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m²28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinosideSingle5.2±0.8 (SD)21.5±16 (SD)95.590-∞ Publications
Orange flavanones Hesperetin sulfoglucuronideHumanUrineHost metabolism786± 135mL of pasteurized orange juicefood24Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m²28.7±4.3 mg Narirutin; 121.5±37.1 mg Hesperidin; 8.25±1.4 mg Isosakuranetin rutinosideSingle72.2 nmol (SD) (0-24h) Publications
Orange flavanones Hesperetin sulfoglucuronideHumanPlasma and UrineHost metabolism786±135 mL of fresh squeezed orange juicefood24Healthy; 12M;12F; Age=27±6; BMI=24±3 Kg/m²4.3±0.7 mg Narirutin; 37.1±3.1 mg Hesperidin; 3.36±3.1 mg Isosakuranetin rutinosideSingle4.3±1 (SD)7±4.5 (SD)36.60-∞ Publications
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