Intervention Studies for the metabolite Isoferulic acid-3'-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 53,39±6,85 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 47,33±3,57 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 0,70 | 51 | 14955 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma | Host metabolism | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,82 | 49 | 17164 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma | Host metabolism | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,97 | 47 | 14783 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma; Urine | Host metabolism | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 1,3±0,2 (SEM) | 69,8±7,3 (SEM) | 493 | (0-24h) | 1,92 | 3.93±0,43 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 6,1±0,4 (SEM) | 121,6±9 (SEM) | 1196,9 | (0-24h) | 1,44 | 8.82µmol(0-24h)±0,96 (SEM) (8.82µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 3,3±0,5 (SEM) | 67,4±6 (SEM) | 600,7 | (0-24h) | 1,44 | 4.26µmol(0-24h)±0,46 (SEM) (4.26µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,03 | 0.24µmol(0-24h)±0,06 (SD) (0.24µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | Tablets | extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 933,00 µmol | Multiple | 4 weeks (3 doses daily) | 1,61 | 15.0µmol(0-24h)±2,2 (SEM) (15.0µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 1,20 | 5.0µmol(0-24h)±(37.;5.3) (IR) (5.0µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 1,40 | 7.1µmol(0-24h)±(5.4;11.3) (IR) (7.1µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 1,10 | 7.7µmol(0-24h)±(5;11.7) (IR) (7.7µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 1,17 | 4.8µmol(0-24h)±0,5 (SEM) (4.8µmol(0-24h)) | Publications |