Glycyrrhetinic acid
precursor
Showing entry for Glycyrrhetinic acid
Identification
- PhytoHub ID
- PHUB000170
- Name
- Glycyrrhetinic acid
- Systematic Name
- Not Available
- Synonyms
- 18β-glycyrrhetinic acid
- Glycyrrhetic acid
- Glycyrrhetic acid (alpha-)
- Glycyrrhetin
- CAS Number
- Not Available
- Average Mass
- 470.694
- Monoisotopic Mass
- 470.339609961
- Chemical Formula
- C30H46O4
- IUPAC Name
- (2S,4aS,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
- InChI Key
- MPDGHEJMBKOTSU-WFJWTYAKSA-N
- InChI Identifier
InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19?,21?,22-,23?,26+,27-,28-,29+,30+/m0/s1
- SMILES
CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]1(C)C2C(=O)C=C2C3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O
- Structure
Calculated Properties
- Solubility (ALOGPS)
- 1.72e-03 g/l
- LogS (ALOGPS)
- -5.44
- LogP (ALOGPS)
- 5.45
- Hydrogen Acceptors
- 4
- Hydrogen Donors
- 2
- Rotatable Bond Count
- 1
- Polar Surface Area
- 74.6
- Refractivity
- 134.2685
- Polarizability
- 55.3864348876561
- Formal Charge
- 0
- Physiological Charge
- -1
- pKa (strongest basic)
- -0.8351069321304386
- pKa (strongest acidic)
- 4.44433188134718
- Number of Rings
- 5
- Rule of Five
- No
- Bioavailability
- Yes
- Ghose Filter
- No
- Veber's Rule
- No
- MDDR-like Rule
- No
External Links
- ChEBI
- 30853
- ChEBI
- 16317
- PubChem
- 10114
- Chemistry Dashboard
- DTXSID9020669
- MetaboLights
- MTBLC30853
- FooDB (Compounds)
- FDB020713
Taxonomy as Food Phytochemical
- Family
- Terpenoids
- Class
- Triterpenoids
- Sub-class
- Saponins
Taxonomy as Metabolite
- Metabolite Family
- Terpenoid metabolites
- Metabolite Class
- Triterpenoid metabolites
- Metabolite Sub-class
- Saponins (parent, host and microbial metabolites)
Taxonomy of its Food Phytochemical Precursor(s)
Food Phytochemical | Family | Class | Sub-class | |
---|---|---|---|---|
Glycyrrhizin | Terpenoids | Triterpenoids | Saponins | Show Food Phytochemical |
Glycyrrhetinic acid | Terpenoids | Triterpenoids | Saponins | Show Food Phytochemical |
Classyfire Taxonomy
- Kingdom Name
- Organic compounds
- Class
- Prenol lipids
- Super-class
- Lipids and lipid-like molecules
- Sub-class
- Triterpenoids
- Direct Parent Name
- Triterpenoids
- Alternative Parent Names
- ["Carboxylic acids", "Cyclic alcohols and derivatives", "Cyclohexenones", "Hydrocarbon derivatives", "Monocarboxylic acids and derivatives", "Organic oxides", "Secondary alcohols"]
- External Descriptor Annotations
- Not Available
- Substituent Names
- ["Alcohol", "Aliphatic homopolycyclic compound", "Carbonyl group", "Carboxylic acid", "Carboxylic acid derivative", "Cyclic alcohol", "Cyclohexenone", "Hydrocarbon derivative", "Ketone", "Monocarboxylic acid or derivatives", "Organic oxide", "Organic oxygen compound", "Organooxygen compound", "Secondary alcohol", "Triterpenoid"]
Spectra from Phytohub
Spectrum Type | Instrument Type | Technology | Ion Mode | Collision Energy | View | |
---|---|---|---|---|---|---|
Predicted GC-MS | GC-MS | Predicted by CFMID-EI, energy0 | Positive | Not Available | View Spectrum | |
Predicted GC-MS | GC-MS | Predicted by CFMID-EI, Ionization energy 70 eV fully TMS-derivatized (structure: CC1(C)C2CC[C@]3(C)C(C(=O)C=C4C5C[C@@](C)(C(=O)O[Si](C)(C)C)CC[C@]5(C)CC[C@]43C)[C@@]2(C)CC[C@@H]1O[Si](C)(C)C) | Positive | Not Available | View Spectrum | |
Predicted GC-MS | GC-MS | Predicted by CFMID-EI, energy0 | Ei | Not Available | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 10V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 20V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 50V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 40V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 10V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 30V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 10V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 20V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 50V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 40V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 10V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 30V | View Spectrum | |
LC-MS/MS | LC-ESI-qTof | From GNPS Library | Positive | V | View Spectrum | |
LC-MS/MS | LC-ESI-QFT | instrument=Q Exactive Plus Orbitrap Thermo Scientific | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QFT | instrument=Q Exactive Plus Orbitrap Thermo Scientific | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QFT | instrument=Q Exactive Plus Orbitrap Thermo Scientific | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QFT | instrument=Q Exactive Plus Orbitrap Thermo Scientific | negative | V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Positive | 10V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Positive | 20V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Positive | 40V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Negative | 10V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Negative | 20V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Negative | 40V | View Spectrum |
Food Sources
Name | Group | |||
---|---|---|---|---|
Liquorice | Confectioneries and desserts | Publications | Show |
Food Sources of its Food Phytochemical(s)
Food Phytochemical | Food Source | Food Source Group | |||
---|---|---|---|---|---|
Glycyrrhizin | Liquorice | Confectioneries and desserts | Publications | Show | |
Glycyrrhetinic acid | Liquorice | Confectioneries and desserts | Publications | Show |
Role as Biomarker of intake
No roles as Biomarker of intake found
Metabolism
Food Phytochemical | Metabolite | Species | Biofluids | Origin | TMax | CMax | Urinary Excretion | Formula | Monoisotopic mass | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycyrrhetinic acid | Glycyrrhetinic acid | human | plasma, urine | unchanged | 3h-5h | 5-20µmol/L | <1% | C30H46O4 | 470.339609961 | Detailed Intervention Studies | Publications | ||
Glycyrrhizin | Glycyrrhetinic acid | human rat | bile, plasma, urine | gut microbiota metabolite | 12h-24h | <20 nmol/L | Not Available | C30H46O4 | 470.339609961 | Detailed Intervention Studies | Publications |
Inter-Individual Variations in Metabolism
Food Phytochemical | Metabolite | Effect | Value |
---|