Identification

PhytoHub ID
PHUB000006
Name
Cafestol
Systematic Name
Not Available
Synonyms
  • (−)-cafestol
  • Cafesterol
CAS Number
Not Available
Average Mass
316.441
Monoisotopic Mass
316.203844762
Chemical Formula
C20H28O3
IUPAC Name
(1S,4S,12S,13R,16S,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0^{1,13}.0^{4,12}.0^{5,9}]nonadeca-5(9),6-dien-17-ol
InChI Key
DNJVYWXIDISQRD-JTSSGKSMSA-N
InChI Identifier
InChI=1S/C20H28O3/c1-18-7-5-16-14(6-9-23-16)15(18)4-8-19-10-13(2-3-17(18)19)20(22,11-19)12-21/h6,9,13,15,17,21-22H,2-5,7-8,10-12H2,1H3/t13-,15+,17-,18+,19-,20-/m0/s1
SMILES
C[[email protected]@]12CCC3=C(C=CO3)[[email protected]]1CC[[email protected]@]13C[[email protected]](CC[[email protected]@H]21)[[email protected]@](O)(CO)C3
Structure

Calculated Properties

Solubility (ALOGPS)
1.80e-02 g/l
LogS (ALOGPS)
-4.24
LogP (ALOGPS)
3.04
Hydrogen Acceptors
2
Hydrogen Donors
2
Rotatable Bond Count
1
Polar Surface Area
53.60000000000001
Refractivity
88.55009999999999
Polarizability
75.87981266270646
Formal Charge
0
Physiological Charge
0
pKa (strongest basic)
-2.7454146697920976
pKa (strongest acidic)
13.685426593369503
Number of Rings
5
Rule of Five
Yes
Bioavailability
Yes
Ghose Filter
Yes
Veber's Rule
No
MDDR-like Rule
No

Taxonomy

Family
Terpenoids
Class
Diterpenoids
Sub-class
Not Available

Classyfire Taxonomy

Kingdom Name
Organic compounds
Class
Naphthofurans
Super-class
Organoheterocyclic compounds
Sub-class
Not Available
Direct Parent Name
Naphthofurans
Alternative Parent Names
["1,2-diols", "Benzofurans", "Cyclic alcohols and derivatives", "Furans", "Heteroaromatic compounds", "Hydrocarbon derivatives", "Oxacyclic compounds", "Primary alcohols", "Tertiary alcohols"]
External Descriptor Annotations
Not Available
Substituent Names
["1,2-diol", "Alcohol", "Aromatic heteropolycyclic compound", "Benzofuran", "Cyclic alcohol", "Furan", "Heteroaromatic compound", "Hydrocarbon derivative", "Naphthofuran", "Organic oxygen compound", "Organooxygen compound", "Oxacycle", "Primary alcohol", "Tertiary alcohol"]

Spectra

No spectra information available

Food Sources

NameGroup
Arabica coffeeCoffee and coffee products PublicationsShow
Arabica coffee oilCoffee and coffee products PublicationsShow
CoffeeCoffee and coffee products PublicationsShow
Robusta coffeeCoffee and coffee products PublicationsShow

Metabolism

PrecursorMetaboliteSpeciesBiofluidsOriginFormulaMonoisotopic mass
Cafestol Cafestol (2-hydroxy-, 3,4-epoxide, glutathione conjugate)mousebileunknownC30H45N3O11S655.277480455 Publications
Cafestol Cafestol (2-hydroxy-)mousebileunknownC20H28O4332.198759382 Publications
Cafestol Cafestol (2-hydroxy-,3,4-epoxide)mousebileunknownC20H28O5348.193674002 Publications
Cafestol Cafestol glucuronidehuman mousebile, blood, urinehost metabolismC26H36O9492.5678392 Publications
Cafestol Cafestol sulfatehumanurinehost metabolismC20H28O6S396.5042844 Publications
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